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Soybean phosphatidylcholine-induced enhancement of lymphatic absorption of triglyceride depends on chylomicron formation in rats.

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タイトル: Soybean phosphatidylcholine-induced enhancement of lymphatic absorption of triglyceride depends on chylomicron formation in rats.
著者: Nishimukai, Megumi 著作を一覧する
Hara, Hiroshi 著作を一覧する
キーワード: lymphatic transport
chylomicron
phosphatidylcholine
発行日: 2007年 5月
出版者: 日本農芸化学会(Japan Society for Bioscience, Biotechnology, and Agrochemistry)JSBBA
誌名: Bioscience Biotechnology and Biochemistry
巻: 71
号: 5
開始ページ: 1192
終了ページ: 1197
出版社 DOI: 10.1271/bbb.60654
抄録: We investigated whether chylomicron formation is involved in the dietary phosphatidylcholine (PC)-induced increase in triglyceride (TG) absorption using an inhibitor of chylomicron formation, pluronic L-81 (L-81). In rats, cannulas were implanted into the duodenum (exps. 1 and 2) and the mesenteric lymph duct (exp. 1), and an emulsified lipid solution containing the test lipids (soybean oil, SO or soybean oil plus phosphatidylcholine, LE) with or without L-81 was infused through a duodenal cannula at a rate 3 ml/h for 2 h, and followed by infusion of a glucose–NaCl solution for 2 h. Mesenteric lymph was collected for 4 h (exp. 1). In exp. 2, the mucosa and contents of the small intestine were collected at 20, 40, or 90 min after the start of duodenal infusion of the test lipid to evaluate accumulation of lipids incorporated into the mucosa in the rats without a lymph cannula. In exp. 1, lymphatic TG outputs rapidly increased with infusion of both test lipids without L-81, but L-81 abolished these increases. TG accumulated in the small intestinal mucosa with L-81 treatment in a time-dependent manner, but the levels of accumulation were similar between the SO and LE groups (exp. 2). There were no differences in the amounts of lipid remaining in the small intestinal lumen between the L-81-treated SO and LE groups. These results indicate that uptake of lipid into the mucosal cells was not increased by LE. We conclude that the formation of chylomicron is responsible for increases in the promotive effect of a high level of dietary PC on the lymphatic absorption of TG.
Relation (URI): http://www.jstage.jst.go.jp/
資料タイプ: article
URI: http://hdl.handle.net/2115/27988
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 原 博

 

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