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Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from holstein cows.

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タイトル: Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from holstein cows.
著者: AHMED, Mohamed 著作を一覧する
SHABAN, Zein 著作を一覧する
YAMAJI, Daisuke 著作を一覧する
OKAMATSU-OGURA, Yuko 著作を一覧する
SOLIMAN, Mohamed 著作を一覧する
ABD ELDAIM, Mabrouk 著作を一覧する
ISHIOKA, Katsumi 著作を一覧する
MAKONDO, Kennedy 著作を一覧する
SAITO, Masayuki 著作を一覧する
KIMURA, Kazuhiro 著作を一覧する
キーワード: caspase-1
発行日: 2007年 5月
出版者: 社団法人 日本獣医学会(The Japanese Society of Veterinary Science)
誌名: Journal of Veterinary Medical Science
巻: 69
号: 5
開始ページ: 509
終了ページ: 514
出版社 DOI: 10.1292/jvms.69.509
抄録: The proliferation of peripheral blood mononuclear cells (PBMC) containing both monocyte/macrophages and T lymphocytes increased after treatment with T-cell mitogen (concanavalin A: Con A). PBMC treated with either leptin alone or combination of leptin and ConA showed enhanced proliferative activity by 10-40%, compared with those treated with ConA alone. In contrast, isolated T lymphocytes treated with leptin and ConA showed lowered proliferative activity than the ConA-treated alone, indicating that leptin induced production of some cytokines from monocyte/macrophages, that subsequently resulted in enhancement of T lymphocytes proliferation in PBMC. Among the cytokines examined, monocyte/monocytes constitutively expressed interleukin (IL)-1β, IL-12p35, IL-18 mRNA, and faintly expressed tumor necrosis factor (TNF)-α and IL-12p40 mRNA. Leptin treatment augmented the monocyte/macrophages mRNA expression of only TNF-α and IL-12p40 to comparable levels of cells treated with lipopolysaccharide (LPS). However, leptin treatment increased monocyte/macrophages production of IL-1β as well as TNF-α, and induced the mRNA expression of caspase-1, which is shown to mediate the conversion of latent pro-IL-1β and pro-IL-18 to active forms. These results suggest that leptin directly acts on monocyte/macrophages to produce factors that induce T lymphocytes proliferation such as IL-12p35/p40 complex through IL-12p40 induction and IL-1β/IL-18 production through caspase-1 induction.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 木村 和弘


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