| Title: | Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic |
| Authors: | Takada, Ayato Browse this author →KAKEN DB |
| Kuboki, Noritaka Browse this author |
| Okazaki, Katsunori Browse this author →KAKEN DB |
| Ninomiya, Ai Browse this author |
| Tanaka, Hiroko Browse this author |
| Ozaki, Hiroichi Browse this author |
| Itamura, Shigeyuki Browse this author |
| Nishimura, Hidekazu Browse this author |
| Enami, Masayoshi Browse this author |
| Tashiro, Masato Browse this author |
| Shortridge, Kennedy F. Browse this author |
| Kida, Hiroshi Browse this author →KAKEN DB |
| Issue Date: | Oct-1999 |
| Publisher: | American Society for Microbiology |
| Journal Title: | Journal of Virology |
| Volume: | 73 |
| Issue: | 10 |
| Start Page: | 8303 |
| End Page: | 8307 |
| Publisher DOI: | 10.1128/JVI.73.10.8303-8307.1999 |
| PMID: | 10482580 |
| Abstract: | In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the virus in the conventional embryonated egg system because of the lethality of the virus for chicken embryos and the high level of biosafety therefore required for vaccine production. Alternative approaches, including an avirulent H5N4 virus isolated from a migratory duck as a surrogate virus, H5N1 virus as a reassortant with avian virus H3N1 and an avirulent recombinant H5N1 virus generated by reverse genetics, have been explored. All vaccines were formalin inactivated. Intraperitoneal immunization of mice with each of vaccines elicited the production of hemagglutination-inhibiting and virus-neutralizing antibodies, while intranasal vaccination without adjuvant induced both mucosal and systemic antibody responses that protected the mice from lethal H5N1 virus challenge. Surveillance of birds and animals, particularly aquatic birds, for viruses to provide vaccine strains, especially surrogate viruses, for a future pandemic is stressed. |
| Rights: | Copyright © 1999 American Society for Microbiology |
| Type: | article |
| URI: | http://hdl.handle.net/2115/28140 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
