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Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic

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Title: Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic
Authors: Takada, Ayato Browse this author →KAKEN DB
Kuboki, Noritaka Browse this author
Okazaki, Katsunori Browse this author →KAKEN DB
Ninomiya, Ai Browse this author
Tanaka, Hiroko Browse this author
Ozaki, Hiroichi Browse this author
Itamura, Shigeyuki Browse this author
Nishimura, Hidekazu Browse this author
Enami, Masayoshi Browse this author
Tashiro, Masato Browse this author
Shortridge, Kennedy F. Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Issue Date: Oct-1999
Publisher: American Society for Microbiology
Journal Title: Journal of Virology
Volume: 73
Issue: 10
Start Page: 8303
End Page: 8307
Publisher DOI: 10.1128/JVI.73.10.8303-8307.1999
PMID: 10482580
Abstract: In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the virus in the conventional embryonated egg system because of the lethality of the virus for chicken embryos and the high level of biosafety therefore required for vaccine production. Alternative approaches, including an avirulent H5N4 virus isolated from a migratory duck as a surrogate virus, H5N1 virus as a reassortant with avian virus H3N1 and an avirulent recombinant H5N1 virus generated by reverse genetics, have been explored. All vaccines were formalin inactivated. Intraperitoneal immunization of mice with each of vaccines elicited the production of hemagglutination-inhibiting and virus-neutralizing antibodies, while intranasal vaccination without adjuvant induced both mucosal and systemic antibody responses that protected the mice from lethal H5N1 virus challenge. Surveillance of birds and animals, particularly aquatic birds, for viruses to provide vaccine strains, especially surrogate viruses, for a future pandemic is stressed.
Rights: Copyright © 1999 American Society for Microbiology
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 喜田 宏

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