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Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.

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Title: Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.
Authors: Ibi, Miho Browse this author
Ishisaki, Akira Browse this author
Yamamoto, Matsuo Browse this author
Wada, Satoshi Browse this author
Kozakai, Takaharu Browse this author
Nakashima, Aiko Browse this author
Iida, Jynichiro Browse this author
Takao, Sonshin Browse this author
Izumi, Yuichi Browse this author
Yokoyama, Atsuro Browse this author
Tamura, Masato Browse this author →KAKEN DB
Keywords: Periodontal ligament
Miniature swine
Endothelial cells
von Willebrand factor
Issue Date: Oct-2007
Publisher: Elsevier Ltd.
Journal Title: Archives of Oral Biology
Volume: 52
Issue: 10
Start Page: 1002
End Page: 1008
Publisher DOI: 10.1016/j.archoralbio.2007.04.009
PMID: 17543882
Abstract: Objective: The periodontal ligament (PDL) is a fibrous connective tissue composed of heterogeneous cell types, including PDL fibroblasts. It is not clear whether cells within the PDL fibroblast population retain the potency to differentiate into other cell types. Design: In the present study, clonal cell lines, derived from Clawn miniature swine PDLs, were established by gene transfection for a human telomerase reverse transcriptase, and characterized. Results: These cell lines, denoted TesPDL1–4, had PDL fibroblasts that showed fibroblastic morphology and expressed procollagen α1(I), osteopontin, periostin and alkaline phosphatase mRNA. Under the specific culture conditions, TesPDL3 cells also have the ability to express CD31, vascular endothelial cadherin, von Willebrand factor, osteocalcin, and to form extracellular mineralized nodules. Conclusions: Our data indicate that TesPDL3 cells have unique properties of expressing several phenotype of fibroblasts, vascular endothelial cells and osteoblasts in cultures.
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田村 正人

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