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Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.

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タイトル: Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.
著者: Ibi, Miho 著作を一覧する
Ishisaki, Akira 著作を一覧する
Yamamoto, Matsuo 著作を一覧する
Wada, Satoshi 著作を一覧する
Kozakai, Takaharu 著作を一覧する
Nakashima, Aiko 著作を一覧する
Iida, Jynichiro 著作を一覧する
Takao, Sonshin 著作を一覧する
Izumi, Yuichi 著作を一覧する
Yokoyama, Atsuro 著作を一覧する
Tamura, Masato 著作を一覧する
キーワード: Periodontal ligament
Miniature swine
Endothelial cells
von Willebrand factor
発行日: 2007年10月
出版者: Elsevier Ltd.
誌名: Archives of Oral Biology
巻: 52
号: 10
開始ページ: 1002
終了ページ: 1008
出版社 DOI: 10.1016/j.archoralbio.2007.04.009
抄録: Objective: The periodontal ligament (PDL) is a fibrous connective tissue composed of heterogeneous cell types, including PDL fibroblasts. It is not clear whether cells within the PDL fibroblast population retain the potency to differentiate into other cell types. Design: In the present study, clonal cell lines, derived from Clawn miniature swine PDLs, were established by gene transfection for a human telomerase reverse transcriptase, and characterized. Results: These cell lines, denoted TesPDL1–4, had PDL fibroblasts that showed fibroblastic morphology and expressed procollagen α1(I), osteopontin, periostin and alkaline phosphatase mRNA. Under the specific culture conditions, TesPDL3 cells also have the ability to express CD31, vascular endothelial cadherin, von Willebrand factor, osteocalcin, and to form extracellular mineralized nodules. Conclusions: Our data indicate that TesPDL3 cells have unique properties of expressing several phenotype of fibroblasts, vascular endothelial cells and osteoblasts in cultures.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 田村 正人


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