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Volume 48, Number 4 >

Mucosal vaccination against influenza : Protection of pigs immunized with inactivated virus and ether-split vaccine

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.48.4.197

Title: Mucosal vaccination against influenza : Protection of pigs immunized with inactivated virus and ether-split vaccine
Authors: LIM, Yoon-Kyu Browse this author
TAKADA, Ayato Browse this author →KAKEN DB
TANIZAKI, Takashi Browse this author
OZAKI, Hiroichi Browse this author
OKAZAKI, Katsunori Browse this author
KIDA, Hiroshi Browse this author →KAKEN DB
Issue Date: 28-Feb-2001
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 48
Issue: 4
Start Page: 197
End Page: 203
Abstract: Effective vaccinations against swine influenza reduce the economic loss of pig industries, and also may minimize the possibility of emergence of new pandemic viruses, since pigs are intermediate hosts to generate reassortant viruses among avian and mammalian influenza viruses. In this study, we showed that intranasal immunization of pigs with formalin-inactivated or ether-split influenza vaccine (A/Aichi/2/68) induced virus-specific IgG, IgM, and IgA antibodies in their nasal secretions and sera, resulting in complete protection from virus challenge. Antibody response to the challenge virus was not observed in the immunized pigs, suggesting that the replication of the virus in the primary targets, respiratory epithelial cells, was inhibited. The present results indicate that intranasal immunization of pigs with inactivated vaccines is effective to control swine influenza, and also provide a good model, as well as a mouse model, to evaluate an intranasal application of influenza vaccine for humans.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2860
Appears in Collections:Japanese Journal of Veterinary Research > Volume 48, Number 4

Submitter: 獣医学部図書室

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