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Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats

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Title: Brain interleukin-1 is involved in blood interleukin-6 response to immobilization stress in rats
Authors: ISHIKAWA, Ikuyo Browse this author
KITAMURA, Hiroshi Browse this author
KIMURA, Kazuhiro Browse this author →KAKEN DB
SAITO, Masayuki Browse this author
Keywords: interleukin-1
Issue Date: 31-May-2001
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 49
Issue: 1
Start Page: 19
End Page: 25
Abstract: Interleukin (IL)-6, a cytokine for host defense responses to infection and imflammation, is known to be induced by non-invasive physical or psychological stress, too. To test possible involvement of brain IL-1 in the stress-induced IL-6 production, IL-1 mRNA expression in the hypothalamus, in parallel with blood IL-6 level, was examined in rats subjected to restriction of their movement (immobilization stress). When rats were immobilized, the hypothalamic IL-1β mRNA level was increased in 1 hr, followed by progressive rises in the serum IL-6 level. The immobilization-induced rise in serum IL-6 was mimicked by intracerebroventricular (icv) administration of IL-1β under normal conditions, whereas it was attenuated by icv injection of an IL-1 receptor antagonist. These results indicate that IL-1 in the hypothalamus plays a pivotal mediating role in the stress-induced peripheral IL-6 production.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 49, Number 1

Submitter: 獣医学部図書室

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