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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Japanese Journal of Veterinary Research >
Volume 49, Number 4 >
Blood meal acquisition by ticks ; molecular advances and implications for vaccine development
| Title: | Blood meal acquisition by ticks ; molecular advances and implications for vaccine development |
| Authors: | MULENGA, Albert Browse this author | | TSUDA, Akiko Browse this author | | SUGIMOTO, Chihiro Browse this author | | ONUMA, Misao Browse this author |
| Keywords: | hemostasis | | platelet aggregation | | vasodilation | | tick vaccine development |
| Issue Date: | 28-Feb-2002 |
| Publisher: | The Graduate School of Veterinary Medicine |
| Journal Title: | Japanese Journal of Veterinary Research |
| Volume: | 49 |
| Issue: | 4 |
| Start Page: | 261 |
| End Page: | 272 |
| Abstract: | In their quest for a blood meal, hematophagous arthropods must first defeat the host's hemostatic defense. Following injury as it occurs when hematophagous arthropods insert their proboscis into host skin to feed, the host will attempt to stop excessive blood loss through its hemostatic defense mechanism involving platelet aggregation, blood clotting and vasoconstriction. To acquire a full blood meal hematophagous arthropods inject an arsenal of bioactive enzymes which ultimately overpower the host's hemostatic defense. We have looked at a selected number of studies on the molecular biology of arthropod anti-hemostatic proteins and developed commentaries on the suitability of these molecules as target tick vaccine antigens. |
| Type: | bulletin (article) |
| URI: | http://hdl.handle.net/2115/2924 |
| Appears in Collections: | Japanese Journal of Veterinary Research > Volume 49, Number 4
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Submitter: 獣医学部図書室
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