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Blood meal acquisition by ticks ; molecular advances and implications for vaccine development

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Title: Blood meal acquisition by ticks ; molecular advances and implications for vaccine development
Authors: MULENGA, Albert Browse this author
TSUDA, Akiko Browse this author
SUGIMOTO, Chihiro Browse this author
ONUMA, Misao Browse this author
Keywords: hemostasis
platelet aggregation
tick vaccine development
Issue Date: 28-Feb-2002
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 49
Issue: 4
Start Page: 261
End Page: 272
Abstract: In their quest for a blood meal, hematophagous arthropods must first defeat the host's hemostatic defense. Following injury as it occurs when hematophagous arthropods insert their proboscis into host skin to feed, the host will attempt to stop excessive blood loss through its hemostatic defense mechanism involving platelet aggregation, blood clotting and vasoconstriction. To acquire a full blood meal hematophagous arthropods inject an arsenal of bioactive enzymes which ultimately overpower the host's hemostatic defense. We have looked at a selected number of studies on the molecular biology of arthropod anti-hemostatic proteins and developed commentaries on the suitability of these molecules as target tick vaccine antigens.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 49, Number 4

Submitter: 獣医学部図書室

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