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Volume 50, Number 2-3 >

Plasma leptin responses to lipopolysaccharide and tumor necrosis factor α in cows

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.50.2-3.107

Title: Plasma leptin responses to lipopolysaccharide and tumor necrosis factor α in cows
Authors: SOLIMAN, Mohamed Browse this author
ISHIOKA, Katsumi Browse this author
KIMURA, Kazuhiro Browse this author →KAKEN DB
KUSHIBIKI, Shiro Browse this author
SAITO, Masayuki Browse this author
Keywords: anorexia
cow
leptin. LPS. TNFα
Issue Date: 29-Nov-2002
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 50
Issue: 2-3
Start Page: 107
End Page: 114
Abstract: Peripheral administration of bacterial lipopolysaccharide (LPS) and various inflammatory cytokines to rodents is known to raise plasma levels of leptin, a potent satiety factor secreted from adipocytes, implying a role of leptin in endotoxin-induced anorexia. We previously reported no effect of LPS on serum leptin levels in sheep, despite marked anorexia and fever. Our results suggest that leptin might not be involved in the endotoxin-induced anorexia in ruminants. To test this idea, in the present study, plasma leptin levels were measured during acute experimental endotoxemia in Holstein cows. Intravenous injection of LPS induced anorexia accompanied with increases in plasma levels of cortisol and insulin, all of which are known to stimulate leptin secretion in rodent and human, while it did not affect plasma leptin levels at all in cows. Similar results were also obtained after injection of recombinant bovine tumor necrosis factor α. These results indicate that plasma leptin levels in cows during acute endotoxemia are differentially regulated from those in rodents, and that leptin might not be involved in the endotoxin-induced anorexia in ruminants.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2955
Appears in Collections:Japanese Journal of Veterinary Research > Volume 50, Number 2-3

Submitter: 獣医学部図書室

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