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Volume 50, Number 4 >

Passive immunization with monoclonal antibodies : effects on Haemaphysalis longicornis tick infestation of BALB/c mice

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.50.4.157

Title: Passive immunization with monoclonal antibodies : effects on Haemaphysalis longicornis tick infestation of BALB/c mice
Authors: Nakajima, Mie Browse this author
Yanase, Haruko Browse this author
Iwanaga, Toshihiko Browse this author →KAKEN DB
Kodama, Michi Browse this author
Ohashi, Kazuhiko Browse this author
Onuma, Misao Browse this author
Keywords: Haemaphysalis longicornis
midgut
monoclonal antibodies
passive immunization
Issue Date: 28-Feb-2003
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 50
Issue: 4
Start Page: 157
End Page: 163
Abstract: Tick vaccine development plays an important role in current tick control strategies. Previously, we have produced three different isotypes of monoclonal antibodies (mAbs) which recognized a midgut protein of adult Haemaphysalis longicornis. These mAbs, typed as IgG1, 2a, and 2b, reacted with a 76 kDa surface protein of midgut cells. We speculated that the 76 kDa protein may be an unknown antigen for a tick vaccine and the three mAbs may work as probes to clone the protein. In this study, to test whether these three isotypes have anti-tick effects and if so which works more effectively, we conducted passive immunization in BALB/c mice with each of the mAbs, and infested the mice with adult ticks. All isotypes significantly reduced the number of hatched larvae, compared to controls, however, no differences in the magnitude of the reduction were observed among the three.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2963
Appears in Collections:Japanese Journal of Veterinary Research > Volume 50, Number 4

Submitter: 獣医学部図書室

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