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Volume 50, Number 4 >

Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys

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この文献には次のDOIがあります:http://doi.org/10.14943/jjvr.50.4.175

タイトル: Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
著者: Kurata, Yoshimasa 著作を一覧する
Katsuta, Osamu 著作を一覧する
Doi, Takuya 著作を一覧する
Kawasuso, Takeshi 著作を一覧する
Hiratsuka, Hideaki 著作を一覧する
Tsuchitani, Minoru 著作を一覧する
Umemura, Takashi 著作を一覧する
キーワード: chronic cadmium toxicosis
cynomolgus monkey
diabetes
islet B cell
pancreas
発行日: 2003年 2月28日
出版者: The Graduate School of Veterinary Medicine
誌名: Japanese Journal of Veterinary Research
巻: 50
号: 4
開始ページ: 175
終了ページ: 183
抄録: In an attempt to establish a primate model of chronic cadmium (Cd) toxicosis, we ovariectomized cynomolgus monkeys and treated with CdCl2 by repeated intravenous injections for 13 to 15 months. The animals showed an increase in blood glucose from Month 10 and a decrease in blood insulin at Month 11 of the Cd-treatment. Histopathological examination of the Cd-treated animals revealed islet atrophy with reduction in islet number and vacuolation of the islet cells, whereas there was no remarkable change in the acinar cells of the exocrine pancreas. In histomorphometrical examination, insulin-positive areas in the islets were significantly decreased, accompanying a relative increase of glucagon-positive areas. Large amounts of Cd accumulated in the pancreas, and metallothionein (MT), a Cd binding protein, was localized in the islets of Cd-treated animals. The present study demonstrated that the chronic intravenous injection of Cd to cynomolgus monkeys induced the accumulation of the metal in the pancreas, degeneration of islet B cells and the diabetic clinical signs. Therefore the islet B cell is one of the major targets of the chronic Cd poisoning in monkeys.
資料タイプ: bulletin
URI: http://hdl.handle.net/2115/2965
出現コレクション:Volume 50, Number 4

 

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