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Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.50.4.175

Title: Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
Authors: Kurata, Yoshimasa Browse this author
Katsuta, Osamu Browse this author
Doi, Takuya Browse this author
Kawasuso, Takeshi Browse this author
Hiratsuka, Hideaki Browse this author
Tsuchitani, Minoru Browse this author
Umemura, Takashi Browse this author →KAKEN DB
Keywords: chronic cadmium toxicosis
cynomolgus monkey
diabetes
islet B cell
pancreas
Issue Date: 28-Feb-2003
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 50
Issue: 4
Start Page: 175
End Page: 183
Abstract: In an attempt to establish a primate model of chronic cadmium (Cd) toxicosis, we ovariectomized cynomolgus monkeys and treated with CdCl2 by repeated intravenous injections for 13 to 15 months. The animals showed an increase in blood glucose from Month 10 and a decrease in blood insulin at Month 11 of the Cd-treatment. Histopathological examination of the Cd-treated animals revealed islet atrophy with reduction in islet number and vacuolation of the islet cells, whereas there was no remarkable change in the acinar cells of the exocrine pancreas. In histomorphometrical examination, insulin-positive areas in the islets were significantly decreased, accompanying a relative increase of glucagon-positive areas. Large amounts of Cd accumulated in the pancreas, and metallothionein (MT), a Cd binding protein, was localized in the islets of Cd-treated animals. The present study demonstrated that the chronic intravenous injection of Cd to cynomolgus monkeys induced the accumulation of the metal in the pancreas, degeneration of islet B cells and the diabetic clinical signs. Therefore the islet B cell is one of the major targets of the chronic Cd poisoning in monkeys.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/2965
Appears in Collections:Japanese Journal of Veterinary Research > Volume 50, Number 4

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