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Remarkable response of juvenile diffuse sclerosing osteomyelitis of mandible to pamidronate.

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Title: Remarkable response of juvenile diffuse sclerosing osteomyelitis of mandible to pamidronate.
Authors: Yamazaki, Yutaka Browse this author
Satoh, Chiharu Browse this author
Ishikawa, Makoto Browse this author
Notani, Ken-ichi Browse this author
Nomura, Katsuhiro Browse this author
Kitagawa, Yoshimasa Browse this author
Issue Date: Jul-2007
Publisher: Mosby, Inc.
Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Volume: 104
Issue: 1
Start Page: 67
End Page: 71
Publisher DOI: 10.1016/j.tripleo.2006.09.021
PMID: 17197211
Abstract: We report a juvenile case of diffuse sclerosing osteomyelitis of the mandible that showed a favorable response to pamidronate, a bisphosphonate derivative. Although conventional treatments had been ineffective for five years, pamidronate administration brought about conspicuous improvement both clinically and radiographically. Severe adverse reaction was not found except for low-grade fever and lassitude only on the day following administration. During the course of the treatment, however, nonsuppurative osteomyelitis of the right humerus also occurred, leading to the established diagnosis of chronic recurrent multifocal osteomyelitis. Then, pamidronate therapy was again performed successfully with almost disappearance of clinical symptoms. Both bone-specific alkaline phosphatase (bone formation marker) and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICPT) (bone resorption marker) showed a marked decrease with pamidronate therapy, which suggested that pamidronate is useful for the treatment of chronic recurrent multifocal osteomyelitis with inhibitory effect on bone turnover.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山崎 裕

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