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Remarkable response of juvenile diffuse sclerosing osteomyelitis of mandible to pamidronate.

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タイトル: Remarkable response of juvenile diffuse sclerosing osteomyelitis of mandible to pamidronate.
著者: Yamazaki, Yutaka 著作を一覧する
Satoh, Chiharu 著作を一覧する
Ishikawa, Makoto 著作を一覧する
Notani, Ken-ichi 著作を一覧する
Nomura, Katsuhiro 著作を一覧する
Kitagawa, Yoshimasa 著作を一覧する
発行日: 2007年 7月
出版者: Mosby, Inc.
誌名: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
巻: 104
号: 1
開始ページ: 67
終了ページ: 71
出版社 DOI: 10.1016/j.tripleo.2006.09.021
抄録: We report a juvenile case of diffuse sclerosing osteomyelitis of the mandible that showed a favorable response to pamidronate, a bisphosphonate derivative. Although conventional treatments had been ineffective for five years, pamidronate administration brought about conspicuous improvement both clinically and radiographically. Severe adverse reaction was not found except for low-grade fever and lassitude only on the day following administration. During the course of the treatment, however, nonsuppurative osteomyelitis of the right humerus also occurred, leading to the established diagnosis of chronic recurrent multifocal osteomyelitis. Then, pamidronate therapy was again performed successfully with almost disappearance of clinical symptoms. Both bone-specific alkaline phosphatase (bone formation marker) and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICPT) (bone resorption marker) showed a marked decrease with pamidronate therapy, which suggested that pamidronate is useful for the treatment of chronic recurrent multifocal osteomyelitis with inhibitory effect on bone turnover.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山崎 裕


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