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Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells

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Title: Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells
Authors: Makondo, Kennedy Browse this author
Kimura, Kazuhiro Browse this author →KAKEN DB
Kitamura, Takanori Browse this author
Yamaji, Daisuke Browse this author
Saito, Masayuki Browse this author
Keywords: Akt
endothelial cell
endothelial cell HGF
nitric oxide synthase
Issue Date: 29-Aug-2003
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 51
Issue: 2
Start Page: 105
End Page: 112
Abstract: Endothelial cells are important for maintenance of vascular integrity by producing a variety of bioactive molecules such as nitric oxide (NO). Recent evidence has suggested that there are some differences in characteristics between endothelial cells from different origins. Here we examined responses of two typical endothelial cells to hepatocyte growth factor (HGF), which induces endothelium-dependent relaxation of microvessels. Stimulation of human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells (BAEC) with HGF increased endothelial NO synthase activity, accompanied with an increase of activity-related site-specific phosphorylation of protein kinase B/Akt. However, HGF stimulated phosphorylation of p38 mitogen-activated protein kinase (MAPK) only in HUVEC, but not in BAEC, while it, induced phosphorylation of p44 /p42 MAPK in both cells. These results suggest that HGF transduces different intracellular signals between aortic and umbilical venous endothelial cells, and that the differences might represent divergent endothelial responses to growth factors, especially those that activate receptor-tyrosine kinases.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 51, Number 2

Submitter: 獣医学部図書室

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