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Volume 51, Number 2 >

Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster

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Title: Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster
Authors: Kim, Hyoung-Ook Browse this author
Kimura, Takashi Browse this author →KAKEN DB
Ochiai, Kenji Browse this author →KAKEN DB
Yazawa, Hajime Browse this author
Itakura, Chitoshi Browse this author
Umemura, Takashi Browse this author →KAKEN DB
Keywords: attractin
black tremor hamster
thyroid hormones
Issue Date: 29-Aug-2003
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 51
Issue: 2
Start Page: 113
End Page: 120
Abstract: Oligodendrocytes and myelin in the corpus callosum of black tremor and normal hamsters aged over 1.5 years were ultrastructurally examined to determine the myelination index (ratio of myelin thickness/diameter of axon), percentage of naked axons, and proportions of oligodendroglial subtypes (light, medium and dark). The mutant hamsters were remarkably hypomyelinated, with a low myelination index and a high proportion of naked axons, and high proportions of the dark subtypes. Serum concentrations of thyroid hormones (T_3 and T_4) in 6-week-old mutant hamsters were 2-fold (T_3) to 3-fold (T_4) higher than those of age-matched normal animals. However, in the aged animals (over 1.5 years old) only T_4 levels of the mutant hamsters were higher in the mutant than normal hamsters. The black tremor hamsters were hypomye-linated throughout their life and high serum level of thyroid hormones might have played a role in the hypomyelination.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 51, Number 2

Submitter: 獣医学部図書室

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