Title: | Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation : a case report |
Authors: | Shono, Yusuke Browse this author |
Toubai, Tomomi Browse this author |
Ota, Shuichi Browse this author |
Ibata, Makoto Browse this author |
Mashiko, Shinobu Browse this author |
Hirate, Daisuke Browse this author |
Miura, Yoko Browse this author |
Umehara, Shintaro Browse this author |
Toyoshima, Nobuyasu Browse this author |
Tanaka, Junji Browse this author |
Asaka, Masahiro Browse this author |
Imamura, Masahiro Browse this author |
Keywords: | Cord blood transplantation (UBT) |
Naïve B lymphocyte |
CD19+27-IgD+ B cells |
IL-6 |
Immunological reconstitution |
Issue Date: | Oct-2006 |
Publisher: | Blackwell Publishing |
Journal Title: | Clinical and Laboratory Haematology |
Volume: | 28 |
Issue: | 5 |
Start Page: | 351 |
End Page: | 354 |
Publisher DOI: | 10.1111/j.1365-2257.2006.00809.x |
PMID: | 16999729 |
Abstract: | A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about
1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells.
Although compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naive B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB. |
Rights: | The definitive version is available at www.blackwell-synergy.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/30131 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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