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Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation : a case report

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Title: Abnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation : a case report
Authors: Shono, Yusuke Browse this author
Toubai, Tomomi Browse this author
Ota, Shuichi Browse this author
Ibata, Makoto Browse this author
Mashiko, Shinobu Browse this author
Hirate, Daisuke Browse this author
Miura, Yoko Browse this author
Umehara, Shintaro Browse this author
Toyoshima, Nobuyasu Browse this author
Tanaka, Junji Browse this author
Asaka, Masahiro Browse this author
Imamura, Masahiro Browse this author
Keywords: Cord blood transplantation (UBT)
Naïve B lymphocyte
CD19+27-IgD+ B cells
IL-6
Immunological reconstitution
Issue Date: Oct-2006
Publisher: Blackwell Publishing
Journal Title: Clinical and Laboratory Haematology
Volume: 28
Issue: 5
Start Page: 351
End Page: 354
Publisher DOI: 10.1111/j.1365-2257.2006.00809.x
PMID: 16999729
Abstract: A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells. Although compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naive B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB.
Rights: The definitive version is available at www.blackwell-synergy.com
Type: article (author version)
URI: http://hdl.handle.net/2115/30131
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 東梅 友美

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