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Coagulation-fibrinolysis is more enhanced in twin than in singleton pregnancies
| Title: | Coagulation-fibrinolysis is more enhanced in twin than in singleton pregnancies |
| Authors: | Morikawa, Mamoru Browse this author →KAKEN DB | | Yamada, Takashi Browse this author | | Turuga, Noriko Browse this author | | Cho, Kazutoshi Browse this author | | Yamada, Hideto Browse this author | | Sakuragi, Noriaki Browse this author →KAKEN DB | | Minakami, Hisanori Browse this author →KAKEN DB |
| Keywords: | antithrombin activity | | coagulation | | D-dimer | | fibrinolysis | | twin |
| Issue Date: | Oct-2006 |
| Publisher: | Walter de Gruyter |
| Journal Title: | Journal of Perinatal Medicine |
| Volume: | 34 |
| Issue: | 5 |
| Start Page: | 392 |
| End Page: | 397 |
| Publisher DOI: | 10.1515/JPM.2006.078 |
| PMID: | 16965226 |
| Abstract: | Aims: To examine whether coagulation-fibrinolysis in late pregnancy in women with twin pregnancies is more pronounced than in women with singleton pregnancies.
Patients and methods: The plasma levels of D-dimer, fibrinogen/fibrin degradation products (FDP), and fibrinogen, the platelet count, and the antithrombin activity were assessed from 3 weeks before delivery until postpartum day 7 in 48 women (24 singleton and 24 twin pregnancies) without preeclampsia who underwent cesarean sections.
Results: Women with singleton or twin pregnancies gave birth at 37.3±1.2 weeks or 35.2±1.4 weeks, respectively. Compared with singleton mothers, prenatal D-dimer and FDP levels were consistently and significantly higher among women with twin pregnancies. A significantly larger proportion of twin mothers exhibited prenatal levels of D-dimer >5.0 μg/mL, FDP >10.0 μg/mL, fibrinogen <420 mg/mL and antithrombin activity <70%. In addition, prenatal antithrombin activity in plasma was significantly lower.
Conclusions: Coagulation-fibrinolysis is more enhanced in women with twin gestation than in women with singleton gestation. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/30132 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 森川 守
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