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Contribution of thermal desorption and liquid–liquid extraction for identification and profiling of impurities in methamphetamine by gas chromatography–mass spectrometry

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タイトル: Contribution of thermal desorption and liquid–liquid extraction for identification and profiling of impurities in methamphetamine by gas chromatography–mass spectrometry
著者: Kuwayama, Kenji 著作を一覧する
Inoue, Hiroyuki 著作を一覧する
Kanamori, Tatsuyuki 著作を一覧する
Tsujikawa, Kenji 著作を一覧する
Miyaguchi, Hajime 著作を一覧する
Iwata, Yuko 著作を一覧する
Kamo, Naoki 著作を一覧する
Kishi, Tohru 著作を一覧する
キーワード: Thermal desorption
Solid phase microextraction
Methamphetamine
Gas chromatography–mass spectrometry
Impurity profiling
発行日: 2007年 8月24日
出版者: Elsevier Ireland Ltd.
誌名: Forensic Science International
巻: 171
号: 1
開始ページ: 9
終了ページ: 15
出版社 DOI: 10.1016/j.forsciint.2006.09.007
抄録: Impurity profiling of methamphetamine (MA) using thermal desorption (TD) and gas chromatography–mass spectrometry (GC–MS) was examined. Using TD/GC–MS, impurities were extracted and separated under various conditions. Optimal chromatograms were obtained when a 20 mg MA sample was extracted at 120 °C for 3 min using a TD instrument, followed by separation of the extracts using a non-polar capillary column coated with (5%phenyl)-methylpolysiloxane. MA samples from nine different batches were analyzed under optimized conditions. Compounds related to the structure of MA, such as benzaldehyde, benzyl alcohol, amphetamine, cis- and trans-1,2-dimethyl-3-phenylaziridine, dimethylamphetamine, and N-acetylephedrine, were detected in the chromatograms without any laborious extraction procedure. Compounds such as ethanol, diethyl ether, and acetic acid, which are considered reagents and solvents for MA synthesis, were also detected in some of the chromatograms. The numbers and intensities of the peaks detected were different among the samples. Impurity profiling of MA using TD was compared with that using liquid–liquid extraction (LLE). Better reproducibility of peak areas was obtained using LLE, whereas higher intensities and numbers of peaks were detected using TD. Solvents were extracted more effectively using TD. The nine batches of MA were classified using both extraction procedures. The nine batches were divided roughly into two groups using data from LLE. Subsequently, the groups were classified in detail using data from TD. TD can be used to provide supplemental information for LLE, and the combination of these extraction methods can be helpful for impurity profiling of MA.
関連URI: http://www.sciencedirect.com/science/journal/03790738
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/30141
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 加茂 直樹

 

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