| Title: | Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma |
| Authors: | Mega, Seiji Browse this author |
| Miyamoto, Masaki Browse this author |
| Li, Li Browse this author |
| Kadoya, Masatoshi Browse this author |
| Takahashi, Ryo Browse this author |
| Hase, Ryunosuke Browse this author |
| Kaneko, Hiroyuki Browse this author |
| Shichinohe, Toshiaki Browse this author →KAKEN DB |
| Kawarada, You Browse this author |
| Itoh, Tomoo Browse this author |
| Morikawa, Toshiaki Browse this author |
| Kondo, Satoshi Browse this author →KAKEN DB |
| Keywords: | survivin |
| esophageal squamous cell carcinoma |
| immunohistochemistry |
| carcinogenesis |
| prognosis |
| Issue Date: | Oct-2006 |
| Publisher: | Blackwell Publishing |
| Journal Title: | Diseases of the Esophagus |
| Volume: | 19 |
| Issue: | 5 |
| Start Page: | 355 |
| End Page: | 359 |
| Publisher DOI: | 10.1111/j.1442-2050.2006.00604.x |
| PMID: | 16984532 |
| Abstract: | Despite advances in the treatment of esophageal carcinoma, the prognosis for this disease remains poor. Therefore, it is important to obtain a better understanding of the molecular basis of esophageal carcinogenesis. The purpose of this study was to clarify the roles of survivin in esophageal squamous cell carcinoma (ESCC). One hundred 22 ESCC surgical specimens resected from 1989 to 1999 were examined. Survivin expression was assessed by immunohistochemistry. Tumor cells were considered survivin-positive if the immunoreactivity was confined to the nucleus, and a scoring method was applied. Survivin-positive immunostaining was detected in 68 patients (56%). There was a significant association between survivin expression and pN (P = 0.0472). Moreover, the overall survival rate was worse in patients with survivin-positive tumors than in patients with survivin-negative tumors (P = 0.0189). The overexpression of survivin was associated with the overall survival rate and poor prognosis in patients with ESCC. Survivin may be targeted during cancer therapy because of its selective expression in malignant tissue. |
| Rights: | The definitive version is available at www.blackwell-synergy.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/30152 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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