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Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma

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Title: Immunohistochemical analysis of nuclear survivin expression in esophageal squamous cell carcinoma
Authors: Mega, Seiji Browse this author
Miyamoto, Masaki Browse this author
Li, Li Browse this author
Kadoya, Masatoshi Browse this author
Takahashi, Ryo Browse this author
Hase, Ryunosuke Browse this author
Kaneko, Hiroyuki Browse this author
Shichinohe, Toshiaki Browse this author →KAKEN DB
Kawarada, You Browse this author
Itoh, Tomoo Browse this author
Morikawa, Toshiaki Browse this author
Kondo, Satoshi Browse this author →KAKEN DB
Keywords: survivin
esophageal squamous cell carcinoma
immunohistochemistry
carcinogenesis
prognosis
Issue Date: Oct-2006
Publisher: Blackwell Publishing
Journal Title: Diseases of the Esophagus
Volume: 19
Issue: 5
Start Page: 355
End Page: 359
Publisher DOI: 10.1111/j.1442-2050.2006.00604.x
PMID: 16984532
Abstract: Despite advances in the treatment of esophageal carcinoma, the prognosis for this disease remains poor. Therefore, it is important to obtain a better understanding of the molecular basis of esophageal carcinogenesis. The purpose of this study was to clarify the roles of survivin in esophageal squamous cell carcinoma (ESCC). One hundred 22 ESCC surgical specimens resected from 1989 to 1999 were examined. Survivin expression was assessed by immunohistochemistry. Tumor cells were considered survivin-positive if the immunoreactivity was confined to the nucleus, and a scoring method was applied. Survivin-positive immunostaining was detected in 68 patients (56%). There was a significant association between survivin expression and pN (P = 0.0472). Moreover, the overall survival rate was worse in patients with survivin-positive tumors than in patients with survivin-negative tumors (P = 0.0189). The overexpression of survivin was associated with the overall survival rate and poor prognosis in patients with ESCC. Survivin may be targeted during cancer therapy because of its selective expression in malignant tissue.
Rights: The definitive version is available at www.blackwell-synergy.com
Type: article (author version)
URI: http://hdl.handle.net/2115/30152
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 妻鹿 成治

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