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Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan
| Title: | Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan |
| Authors: | Endo, Rika Browse this author | | Ishiguro, Nobuhisa Browse this author →KAKEN DB | | Kikuta, Hideaki Browse this author | | Teramoto, Shinobu Browse this author | | Shirkoohi, Reza Browse this author | | Ma, Xiaoming Browse this author | | Ebihara, Takashi Browse this author | | Ishiko, Hiroaki Browse this author | | Ariga, Tadashi Browse this author |
| Issue Date: | Oct-2007 |
| Publisher: | American Society for Microbiology |
| Journal Title: | Journal of Clinical Microbiology |
| Volume: | 45 |
| Issue: | 10 |
| Start Page: | 3218 |
| End Page: | 3223 |
| Publisher DOI: | 10.1128/JCM.02140-06 |
| PMID: | 17699639 |
| Abstract: | A new human virus, provisionally named human bocavirus (HBoV), was discovered by Swedish researchers in 2005. A new immunofluorescence assay using Trichoplusia ni insect cells infected with a recombinant baculovirus expressing the VP1 protein of HBoV was developed, and the levels of immunoglobulin G antibody to the VP1 protein of HBoV in serum samples were measured. The overall seroprevalence rate of antibodies against the VP1 protein of HBoV in a Japanese population aged from 0 months to 41 years was 71.1% (145 of 204). The seropositive rate was lowest in the age group of 6 to 8 months and gradually increased with age. All of the children had been exposed to HBoV by the age of 6 years. A rise in titers of antibody against the VP1 protein of HBoV during the convalescent phase was observed for four patients with lower respiratory tract infections, and HBoV DNA was detected in nasopharyngeal swab and serum samples from all four patients. These results suggest that HBoV is a ubiquitous virus acquired early in life and that HBoV might play a role in the course of lower respiratory tract infections. |
| Rights: | Copyright © American Society for Microbiology |
| Type: | article |
| URI: | http://hdl.handle.net/2115/30195 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石黒 信久
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