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Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan

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Title: Seroepidemiology of Human Bocavirus in Hokkaido Prefecture, Japan
Authors: Endo, Rika Browse this author
Ishiguro, Nobuhisa Browse this author →KAKEN DB
Kikuta, Hideaki Browse this author
Teramoto, Shinobu Browse this author
Shirkoohi, Reza Browse this author
Ma, Xiaoming Browse this author
Ebihara, Takashi Browse this author
Ishiko, Hiroaki Browse this author
Ariga, Tadashi Browse this author
Issue Date: Oct-2007
Publisher: American Society for Microbiology
Journal Title: Journal of Clinical Microbiology
Volume: 45
Issue: 10
Start Page: 3218
End Page: 3223
Publisher DOI: 10.1128/JCM.02140-06
PMID: 17699639
Abstract: A new human virus, provisionally named human bocavirus (HBoV), was discovered by Swedish researchers in 2005. A new immunofluorescence assay using Trichoplusia ni insect cells infected with a recombinant baculovirus expressing the VP1 protein of HBoV was developed, and the levels of immunoglobulin G antibody to the VP1 protein of HBoV in serum samples were measured. The overall seroprevalence rate of antibodies against the VP1 protein of HBoV in a Japanese population aged from 0 months to 41 years was 71.1% (145 of 204). The seropositive rate was lowest in the age group of 6 to 8 months and gradually increased with age. All of the children had been exposed to HBoV by the age of 6 years. A rise in titers of antibody against the VP1 protein of HBoV during the convalescent phase was observed for four patients with lower respiratory tract infections, and HBoV DNA was detected in nasopharyngeal swab and serum samples from all four patients. These results suggest that HBoV is a ubiquitous virus acquired early in life and that HBoV might play a role in the course of lower respiratory tract infections.
Rights: Copyright © American Society for Microbiology
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石黒 信久

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