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Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and magnetic resonance axonography

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Title: Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and magnetic resonance axonography
Other Titles: Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and MR-axonography
Authors: Aoyama, Hidefumi Browse this author
Kamada, Kyousuke Browse this author
Shirato, Hiroki Browse this author
Takeuchi, Fumiya Browse this author
Kuriki, Shinya Browse this author
Iwasaki, Yoshinobu Browse this author
Miyasaka, Kazuo Browse this author
Keywords: Radiosurgery
Magnetoencephalography
Axon
Function
Arteriovenous malformation
Issue Date: 15-Mar-2004
Publisher: Elsevier Inc.
Journal Title: International Journal of Radiation Oncology'Biology'Physics
Volume: 58
Issue: 4
Start Page: 1177
End Page: 1183
Publisher DOI: 10.1016/j.ijrobp.2003.08.034
PMID: 15001262
Abstract: Purpose: To minimize the risk of neurologic deficit after stereotactic irradiation, functional brain information was integrated into treatment planning. Methods and materials: Twenty-one magnetoencephalography and six magnetic resonance axonographic images were made in 20 patients to evaluate the sensorimotor cortex (n = 15 patients, including the corticospinal tract in 6), visual cortex (n = 4), and Wernicke's area (n = 2). One radiation oncologist was asked to formulate a treatment plan first without the functional images and then to modify the plan after seeing them. The pre- and postmodification values were compared for the volume of the functional area receiving ≥15 Gy and the volume of the planning target volume receiving ≥80% of the prescribed dose. Results: Of the 21 plans, 15 (71%) were modified after seeing the functional images. After modification, the volume receiving ≥15 Gy was significantly reduced compared with the values before modification in those 15 sets of plans (p = 0.03). No statistically significant difference was found in the volume of the planning target volume receiving ≥80% of the prescribed dose (p = 0.99). During follow-up, radiation-induced necrosis at the corticospinal tract caused a minor motor deficit in 1 patient for whom magnetic resonance axonography was not available in the treatment planning. No radiation-induced functional deficit was observed in the other patients. Conclusion: Integration of magnetoencephalography and magnetic resonance axonography in treatment planning has the potential to reduce the risk of radiation-induced functional dysfunction without deterioration of the dose distribution in the target volume.
Relation: http://www.sciencedirect.com/science/journal/03603016
Type: article (author version)
URI: http://hdl.handle.net/2115/30201
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 青山 英史

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