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Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and magnetic resonance axonography
| Title: | Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and magnetic resonance axonography |
| Other Titles: | Integration of functional brain information into stereotactic irradiation treatment planning using magnetoencephalography and MR-axonography |
| Authors: | Aoyama, Hidefumi Browse this author | | Kamada, Kyousuke Browse this author | | Shirato, Hiroki Browse this author | | Takeuchi, Fumiya Browse this author | | Kuriki, Shinya Browse this author | | Iwasaki, Yoshinobu Browse this author | | Miyasaka, Kazuo Browse this author |
| Keywords: | Radiosurgery | | Magnetoencephalography | | Axon | | Function | | Arteriovenous malformation |
| Issue Date: | 15-Mar-2004 |
| Publisher: | Elsevier Inc. |
| Journal Title: | International Journal of Radiation Oncology'Biology'Physics |
| Volume: | 58 |
| Issue: | 4 |
| Start Page: | 1177 |
| End Page: | 1183 |
| Publisher DOI: | 10.1016/j.ijrobp.2003.08.034 |
| PMID: | 15001262 |
| Abstract: | Purpose: To minimize the risk of neurologic deficit after stereotactic irradiation, functional brain information was integrated into treatment planning.
Methods and materials: Twenty-one magnetoencephalography and six magnetic resonance axonographic images were made in 20 patients to evaluate the sensorimotor cortex (n = 15 patients, including the corticospinal tract in 6), visual cortex (n = 4), and Wernicke's area (n = 2). One radiation oncologist was asked to formulate a treatment plan first without the functional images and then to modify the plan after seeing them. The pre- and postmodification values were compared for the volume of the functional area receiving ≥15 Gy and the volume of the planning target volume receiving ≥80% of the prescribed dose.
Results: Of the 21 plans, 15 (71%) were modified after seeing the functional images. After modification, the volume receiving ≥15 Gy was significantly reduced compared with the values before modification in those 15 sets of plans (p = 0.03). No statistically significant difference was found in the volume of the planning target volume receiving ≥80% of the prescribed dose (p = 0.99). During follow-up, radiation-induced necrosis at the corticospinal tract caused a minor motor deficit in 1 patient for whom magnetic resonance axonography was not available in the treatment planning. No radiation-induced functional deficit was observed in the other patients.
Conclusion: Integration of magnetoencephalography and magnetic resonance axonography in treatment planning has the potential to reduce the risk of radiation-induced functional dysfunction without deterioration of the dose distribution in the target volume. |
| Relation: | http://www.sciencedirect.com/science/journal/03603016 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/30201 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 青山 英史
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