| Title: | Effect of granulocyte colony-stimulating factor on IL-12 p40 production during chemotherapy for B-cell lineage non-Hodgkin's lymphoma patients |
| Authors: | Toubai, Tomomi Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Ota, Shuichi Browse this author |
| Fukuhara, Takashi Browse this author |
| Hashino, Satoshi Browse this author →KAKEN DB |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Shono, Yusuke Browse this author |
| Morioka, Masanobu Browse this author |
| Kawamura, Tsugumichi Browse this author |
| Masauzi, Nobuo Browse this author |
| Kakinoki, Yasutaka Browse this author |
| Kobayashi, Hajime Browse this author |
| Kunieda, Yasuyuki Browse this author |
| Kasai, Masaharu Browse this author |
| Kurosawa, Mitsutoshi Browse this author |
| Asaka, Masahiro Browse this author |
| Imamura, Masahiro Browse this author |
| Keywords: | IL-12 |
| IL-12 p40 |
| IL-12 p35 |
| non-Hodgkin’s lymphoma |
| G-CSF |
| Issue Date: | Nov-2006 |
| Publisher: | Blackwell Publishing |
| Journal Title: | European Journal Of Haematology |
| Volume: | 77 |
| Issue: | 5 |
| Start Page: | 403 |
| End Page: | 409 |
| Publisher DOI: | 10.1111/j.1600-0609.2006.00746.x |
| PMID: | 16930137 |
| Abstract: | Interleukin (IL)-12 is a 70-kDa cytokine comprised of two disulfide-linked proteins (p35 and p40) and is essential for the initiation of effective immune response. Granulocyte-colony stimulating factor (G-CSF) affects the balance in the production of anti-inflammatory cytokines. We investigated the serum IL-12 p40 and IL-12 Mix (p40 and p70) production in 28 patients with B-cell lineage non-Hodgkin's lymphoma (NHL) treated with chemotherapy (e.g., CHOP regimen) with or without G-CSF administration and eight healthy volunteers. We found that serum levels of IL-12 p40 (191.2 ± 150.0 pg/mL) and IL-12 Mix (277.4 ± 274.5 pg/mL) in the patients before chemotherapy were higher than those in the healthy volunteers (IL-12 p40: 76.4 ± 25.3 pg/mL, IL-12 Mix: 48.5 ± 33.4 pg/mL) (P = 0.04 and 0.02, respectively). Next, we examined the serum IL-12 p40 and IL-12 Mix levels in nine patients receiving chemotherapy with administration of G-CSF (CG group, n = 9) and without G-CSF (C group, n = 9). Serum IL-12 p40 and IL-12 Mix levels were decreased on 10 d after chemotherapy in both groups, and those in CG groups were significantly lower than those in C group. These results indicated that administration of G-CSF decreased serum IL-12 p40 and IL-12 Mix levels. Overall survival (OS) at 24 months was not significantly different in the two groups (58.3% in group C vs. 80.0% in group CG, P = 0.67). However, the survival rate of patients at clinical stages III and IV in CG group (n = 6, 66.0%) was significantly better than that of patients in C group (n = 4, 25.0%) (P = 0.02). Long-term administration of G-CSF appears to influence the survival rate by reducing immunosuppressive IL-12 p40 production. |
| Rights: | The definitive version is available at www.blackwell-synergy.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/30221 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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