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Volume 35, Number 1 >

MITOGENIC RESPONSIBILITIES OF LYMPHOCYTES IN CANINE BABESIOSIS AND THE EFFECTS OF SPLENECTOMY ON IT

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.35.1.1

Title: MITOGENIC RESPONSIBILITIES OF LYMPHOCYTES IN CANINE BABESIOSIS AND THE EFFECTS OF SPLENECTOMY ON IT
Authors: KAWAMURA, Masahiro Browse this author
MAEDE, Yoshimitsu Browse this author →KAKEN DB
NAMIOKA, Shigeo Browse this author
Keywords: Babesia gibsoni
canine babesiosis
canine lymphocytes
splenectomy
Issue Date: 30-Jan-1987
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 35
Issue: 1
Start Page: 1
End Page: 10
Abstract: In order to clarify the mechanisms of immune-responses in canine babesiosis, mitogen-induced transformation of lymphocytes from peripheral blood and its relation to parasitemia were chiefly examined in both intact and splenectomized dogs suffering from Babesia gibsoni. The lymphocyte responses to PHA-P, Con A and PWM in dogs infected with B. gibsoni were all extremely depressed as the parasite increased in their peripheral blood. The lymphocyte responses to the mitogens greatly decreased after splenectomy in both groups infected and noninfected with B. gibsoni. Furthermore, severe relapse of parasitemia appeared in the infected dogs after splenectomy. Mild parasitemia and moderate anemia were prolonged for at least 3 months with a high serum IFA titer to the parasite in splenectomized dogs.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/3026
Appears in Collections:Japanese Journal of Veterinary Research > Volume 35, Number 1

Submitter: 獣医学部図書室

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