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In vivo effects of partial electrothermal shrinkage on mechanical properties of the anterior cruciate ligament in rabbits

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Title: In vivo effects of partial electrothermal shrinkage on mechanical properties of the anterior cruciate ligament in rabbits
Authors: Kondo, Eiji Browse this author
Yasuda, Kazunori Browse this author →KAKEN DB
Tohyama, Harukazu Browse this author →KAKEN DB
Keywords: Anterior cruciate ligament
Biomechanics
Radiofrequency
Shrinkage
In vivo study
Issue Date: Nov-2007
Publisher: Elsevier Ltd.
Journal Title: Clinical Biomechanics
Volume: 22
Issue: 9
Start Page: 1037
End Page: 1044
Publisher DOI: 10.1016/j.clinbiomech.2007.07.002
PMID: 17723257
Abstract: Background: No studies have been conducted to clarify an in vivo remodeling of the radiofrequency-treated lesion of the anterior cruciate ligament. The purpose was to determine in vivo effects of radiofrequency shrinkage on mechanical properties of the anterior cruciate ligament. Methods: Thirty skeletally mature rabbits were used. In each group, radiofrequency energy set at non-ablative levels was applied to the posterolateral bundle of the anterior cruciate ligament with a bipolar radiofrequency generator. All animals were sacrificed at 0, 6, and 12 weeks after surgery, respectively. In each group, 7 and 3 out of the 10 specimens were used for biomechanical and histological evaluations. Findings: After shrinkage treatment, the anterior–posterior translation of the knee and the length of the posterolateral bundle were significantly reduced immediately after surgery, but that this effect disappeared at 6 weeks. The tensile strength and the tangent modulus of the treated bundle were significantly lower than that of the normal control bundle at each period. In addition, the tensile strength and the tangent modulus measured at 12 weeks were significantly lower than that at 0 week. Histological examination showed granulation-like tissues with numerous plump fibroblasts and inflammatory cells were dominantly found in the midsubstance of the posterolateral bundle at 12 weeks. Interpretations: This result suggested that the anterior cruciate ligament tissue shortened with the radiofrequency treatment is elongated gradually over time. The mechanical properties of the posterolateral bundle of the anterior cruciate ligament reduced by the radiofrequency shrinkage are not restored in vivo, but significantly deteriorated with time.
Relation: http://www.sciencedirect.com/science/journal/02680033
Type: article (author version)
URI: http://hdl.handle.net/2115/30265
Appears in Collections:創成研究機構 (Creative Research Institution) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 近藤 英司

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