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Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells

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タイトル: Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells
著者: Onoé, Kazunori 著作を一覧する
Yanagawa, Yoshiki 著作を一覧する
Minami, Keita 著作を一覧する
Iijima, Norifumi 著作を一覧する
Iwabuchi, Kazuya 著作を一覧する
キーワード: Th1/Th2
Dendritic cells
NKT cells
Feedback regulation
発行日: 2007年 7月
出版者: Humana Press Inc.
誌名: Immunologic Research
巻: 38
号: 1-3
開始ページ: 319
終了ページ: 332
出版社 DOI: 10.1007/s12026-007-0011-5
抄録: If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by α-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.
Rights: The original publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小野江 和則


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