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Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells

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Title: Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells
Authors: Onoé, Kazunori Browse this author
Yanagawa, Yoshiki Browse this author
Minami, Keita Browse this author
Iijima, Norifumi Browse this author
Iwabuchi, Kazuya Browse this author
Keywords: Th1/Th2
Dendritic cells
NKT cells
Feedback regulation
Issue Date: Jul-2007
Publisher: Humana Press Inc.
Journal Title: Immunologic Research
Volume: 38
Issue: 1-3
Start Page: 319
End Page: 332
Publisher DOI: 10.1007/s12026-007-0011-5
Abstract: If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by α-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野江 和則

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