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Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA

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Title: Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA
Authors: Maruyama, Satoru Browse this author
Miyajima, Naoto Browse this author
Bohgaki, Miyuki Browse this author
Tsukiyama, Tadasuke Browse this author
Shigemura, Masahiko Browse this author
Nonomura, Katsuya Browse this author
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: PIRH2
androgen receptor
Issue Date: Jan-2008
Publisher: Springer
Journal Title: Molecular and Cellular Biochemistry
Volume: 307
Issue: 1-2
Start Page: 73
End Page: 82
Publisher DOI: 10.1007/s11010-007-9586-3
PMID: 17721809
Abstract: Ubiquitylation appears to be involved in the membrane trafficking system including endocytosis, exocytosis, and ER-to-Golgi transport. We found that PIRH2, which was identified as an interacting protein for androgen receptor or p53, interacts with and ubiquitylates the ε-subunit of coatmer complex, ε-COP. PIRH2 promotes the ubiquitylation of ε-COP in vitro and in vivo and consequently promotes the degradation of ε-COP. The interaction between PIRH2 and ε-COP is affected by the presence of androgen, and PIRH2 in the presence of androgen promotes ubiquitylation of ε-COP in vivo. Furthermore, overexpression of the wild type of PIRH2 in prostate cancer cells causes downregulation of the secretion of prostate-specific antigen (PSA), a secretory protein in prostate epithelial cells and one of diagnostic markers for prostate cancer. Our results indicate that PIRH2 functions as a regulator for COP I complex.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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