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Volume 55, Number 2-3 >

Development of vaccine strains of H5 and H7 influenza viruses

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Title: Development of vaccine strains of H5 and H7 influenza viruses
Authors: Soda, Kosuke Browse this author
Sakoda, Yoshihiro Browse this author →KAKEN DB
Isoda, Norikazu Browse this author
Kajihara, Masahiro Browse this author
Haraguchi, Yoshinari Browse this author
Shibuya, Hitomi Browse this author
Yoshida, Hiromi Browse this author
Sasaki, Takashi Browse this author
Sakamoto, Ryuichi Browse this author
Saijo, Kazue Browse this author
Hagiwara, Junko Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Keywords: genetic reassortant
Issue Date: 9-Feb-2008
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 55
Issue: 2-3
Start Page: 93
End Page: 98
Abstract: To establish vaccine strains of H5 and H7 influenza viruses, A/duck/Hokkaido/Vac-1/04 (H5N1) [Vac-1/04 (H5N1)], A/duck/Hokkaido/Vac-3/07 (H5N1) [Vac-3/07 (H5N1)], and A/duck/Hokkaido/ Vac-2/04 (H7N7) [Vac-2/04 (H7N7)] were generated from non-pathogenic avian influenza viruses isolated from migratory ducks. Vac-1/04 (H5N1) and Vac-3/07 (H5N1) were generated by genetic reassortment between H5N2 or H5N3 virus as an HA gene provider and H7N1 or H6N1 viruses as an NA gene provider. Vac-2/04 (H7N7) was a genetic reassortant obtained using H7N7 and H9 N2 viruses to give high growth character of the H9N2 virus in chicken embryonated eggs. The results of sequence analyses and experimental infections revealed that these H5N1 and H7N7 reassortant viruses were non-pathogenic in chickens and embryos, and had good growth potential in embryonated eggs. These viruses should be useful to develop vaccines against H5 and H7 highly pathogenic avian influenza viruses.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 55, Number 2-3

Submitter: 獣医学部図書室

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