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Steep dose-response relationship for stage I non-small cell lung cancer using hypo-fractionated high-dose irradiation by real-time tumor-tracking radiotherapy (RTRT)

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Title: Steep dose-response relationship for stage I non-small cell lung cancer using hypo-fractionated high-dose irradiation by real-time tumor-tracking radiotherapy (RTRT)
Authors: Onimaru, Rikiya Browse this author →KAKEN DB
Fujino, Masaharu Browse this author
Yamazaki, Koichi Browse this author
Onodera, Yuya Browse this author
Taguchi, Hiroshi Browse this author
Katoh, Norio Browse this author →KAKEN DB
Hommura, Fumihiro Browse this author
Oizumi, Satoshi Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: real-time tumor-tracking radiotherapy
stereotactic radiotherapy
lung cancer
Issue Date: 1-Feb-2008
Publisher: Elsevier
Journal Title: International Journal of Radiation Oncology*Biology*Physics
Volume: 70
Issue: 2
Start Page: 374
End Page: 381
Publisher DOI: 10.1016/j.ijrobp.2007.06.043
PMID: 18029106
Abstract: Purpose: To investigate the clinical outcomes of patients with pathologically proven, peripherally located, stage I non-small cell lung cancer (NSCLC) who received stereotactic body radiotherapy (SBRT) using real-time tumor tracking radiotherapy (RTRT) during the developmental period. Materials and Methods: Forty-one patients were admitted (T1, 25; T2, 16) from February 2000 to June 2005. A 5 mm lanning target volume (PTV) margin was added to the clinical target volume determined with computed tomography at the end of expiratory phase. The gating window ranged from ± 2 to 3 mm. The dose fractionation schedule was 40 or 48 Gy in 4 fractions within 7 days. The dose was prescribed at the center of the PTV, giving more than an 80% dose at the PTV periphery. Results: For 28 patients treated with 48 Gy in 4 fractions, the overall actuarial survival (OAS) at 3 years was 82% for stage IA and 32% for stage IB. For patients treated with 40Gy/4Fr/1wk, OAS at 3 years was 50% for stage IA and 0% for stage IB. There was a significant difference in local control between 40 and 48 Gy in stage IB (p=0.0015) but not in stage IA (p=0.5811). No serious radiation morbidity was observed in either dose schedule. Conclusion: Forty-eight Gy in 4 fractions in one week was found to be a safe and effective treatment for peripherally located, stage IA NSCLC. A steep dose-response curve between 40 and 48 Gy using a daily dose of 12 Gy delivered in one week was identified for stage IB NSCLC in SBRT using RTRT.
Relation: http://www.sciencedirect.com/science/journal/03603016
Type: article (author version)
URI: http://hdl.handle.net/2115/33040
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鬼丸 力也

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