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Spindle Cell-Type Undifferentiated Carcinoma of the Common Bile Duct of the Hepatic Hilus

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Title: Spindle Cell-Type Undifferentiated Carcinoma of the Common Bile Duct of the Hepatic Hilus
Other Titles: Spindle cell carcinoma of the common bile duct
Authors: Nakanishi, Yoshitsugu Browse this author
Ito, Tomoo Browse this author
Kubota, Kanako Browse this author
Takeda, Hiroko Browse this author
Yonemori, Atsuya Browse this author
Kawakami, Hiroshi Browse this author
Zen, Yoh Browse this author
Kondo, Satoshi Browse this author
Keywords: undifferentiated carcinoma
sarcomatous carcinoma
spindle cell
common bile duct of the hepatic hilus
Issue Date: Aug-2007
Publisher: Springer Japan
Journal Title: Surgery Today
Volume: 37
Issue: 8
Start Page: 708
End Page: 712
Publisher DOI: 10.1007/s00595-007-3463-2
PMID: 17643221
Abstract: Spindle cell-type undifferentiated carcinoma arising from the extrahepatic bile duct is extremely rare. We report herein a case of this type of carcinoma in the common bile duct of the hepatic hilus. A 59-year-old man was admitted to our hospital complaining of jaundice. Laboratory data revealed elevation of serum CA 19-9. Cholangiography revealed complete obliteration of the left hepatic bile duct and stenosis of the bile duct from the superior to the right hepatic bile duct. Computed tomography showed the tumor, measuring 15×12 mm, in the hepatic hilus, obliteration of the right to main trunk of the portal vein and a lymph node in the hepato-duodenum ligament swelling. Arteriography revealed a kink of the right hepatic artery, so encasement of the right hepatic artery was suspected. We preoperatively diagnosed hilus bile duct carcinoma and scheduled right trisection hepatectomy. Intraoperative frozen sections taken from the tumor and tissues around hepatic arteries showed spindle cells and inflammatory cells, so inflammatory pseudotumor was diagnosed intraoperatively. Because the right hepatic bile duct was occluded, right lobe hepatectomy was performed. However, permanent section revealed both spindle cells and poorly differentiated tubular adenocarcinoma cells positive for CAM5.2, AE1/AE3 and vimentin. Based on these findings, the tumor was finally diagnosed as spindle cell-type undifferentiated carcinoma. The patient died of pulmonary infarction 11 days after the operation.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中西 喜嗣

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