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Mechanism of apoptosis induced by copper in PC12 cells

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Title: Mechanism of apoptosis induced by copper in PC12 cells
Authors: Kawakami, Masaki Browse this author
Inagawa, Rieko Browse this author
Hosokawa, Toshiyuki Browse this author
Saito, Takeshi Browse this author
Kurasaki, Masaaki Browse this author
Keywords: apoptosis
PC12 cell
cytochrome c
Bcl-2 family
Issue Date: Jun-2008
Publisher: Pergamon-Elsevier Science
Journal Title: Food and Chemical Toxicology
Volume: 46
Issue: 6
Start Page: 2157
End Page: 2164
Publisher DOI: 10.1016/j.fct.2008.02.014
PMID: 18381230
Abstract: Copper, an essential trace element, induces apoptosis in mammalian cells. However, the precise mechanism of copper-induced apoptosis is still unclear. In this study, to determine the apoptotic pathway initiated by copper treatment, apoptotic factors such as Bax, Bad and Bcl-2, and the caspase family in PC 12 cells treated with copper were measured by Western blot and RT-PCR analyses. The expression of Bax, Bad, cytochrome c and caspases 3 and 9 were increased by copper treatment. From these results, two pathways for copper-induced apoptosis were suggested. At first, an increase of Bax induces the release of cytochrome c from the mitochondria into the cytoplasm owing to binding to apoptotic activating caspase 9 leading to the activation of caspases 3. In the other pathway an increase of Bax and reactive oxygen species activates the release of AIF from the mitochondria. The AIF induces apoptosis via a caspase-independent pathway.
Type: article (author version)
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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