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Participation of the Fas and Fas ligand systems in apoptosis during atrophy of the rat submandibular glands

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Title: Participation of the Fas and Fas ligand systems in apoptosis during atrophy of the rat submandibular glands
Other Titles: Fas systems in salivary gland atrophy
Authors: Takahashi, Shigeru Browse this author →KAKEN DB
Gobe, Glenda C. Browse this author
Yoshimura, Yoshitaka Browse this author
Kohgo, Takao Browse this author
Yamamoto, Tsuneyuki Browse this author
Wakita, Minoru Browse this author
Keywords: Fas
Fas ligand
submandibular gland
Issue Date: Feb-2007
Publisher: Blackwell
Journal Title: International Journal of Experimental Pathology
Volume: 88
Issue: 1
Start Page: 9
End Page: 17
Publisher DOI: 10.1111/j.1365-2613.2006.00511.x
Abstract: Most acinar cells and some duct cells undergo apoptosis during atrophy of the submandibular gland. The present study was designed to elucidate whether Fas and its receptor ligand (FasL) are involved during apoptotic atrophy of the gland. The excretory duct of the right submandibular gland of rats was doubly ligated with metal clips from 1 to 14 days for induction of gland atrophy. Control rats were untreated. Fas and FasL expression in the atrophied submandibular gland was detected using immunohistochemistry (IHC) and Western immunoblot. Expression of activated caspase 8 and activated caspase 3 was also detected with IHC. Fas-positive acinar and duct cells and FasL-positive duct cells increased in the atrophic glands at 3 and 5 days after duct ligation when apoptotic cells were commonly observed. Thereafter, Fas- and FasL-positive cells declined in number. Patterns of expression of Fas and FasL using Western immunoblots concurred with the IHC results. Activated caspase 8-positive cells were present at every time interval but peaked at 3 and 5 days following duct ligation. The cells showing immunoreaction for activated caspase 3 first appeared on day 3, with the peak in apoptosis, after which they decreased. The results indicate that the Fas/FasL systems likely play an important role in apoptotic pathways during atrophy of the submandibular gland.
Rights: The definitive version is available at
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 茂

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