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Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.

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Title: Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.
Authors: Horie, Yukihiro Browse this author
Takemoto, Yuko Browse this author →KAKEN DB
Miyazaki, Akiko Browse this author
Namba, Kenichi Browse this author →KAKEN DB
Kase, Satoru Browse this author →KAKEN DB
Yoshida, Kazuhiko Browse this author →KAKEN DB
Ota, Masao Browse this author
Hasumi, Yukiko Browse this author
Inoko, Hidetoshi Browse this author
Mizuki, Nobuhisa Browse this author
Ohno, Shigeaki Browse this author →KAKEN DB
Issue Date: 20-Dec-2006
Publisher: Molecular Vision
Journal Title: Molecular Vision
Volume: 12
Start Page: 1601
End Page: 1605
PMID: 17200659
Abstract: PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)). METHODS: 87 VKH patients and 122 healthy controls were genotyped using seven microsatellite markers on the candidate loci. We analyzed microsatellite (MS) polymorphisms at regions within tyrosinase gene family loci. In addition, the haplotype frequencies were also estimated and statistical analysis was performed. HLA-DRB1 genotyping was performed by the PCR-restriction fragment length polymorphism (RFLP) method. RESULTS: No significant evidence for an association was found. HLA-DRB1*0405 showed a highly significant association with VKH disease compared with the healthy controls (Pc=0.000000079), as expected. CONCLUSIONS: We concluded that there is no genetic susceptibility or increased risk attributed to the tyrosinase gene family. Our results suggest the need for further genetic study and encourage a search for novel genetic loci and predisposing genes in order to elucidate the genetic mechanisms underlying VKH disease.
Rights: Copyright (c) 2006 Molecular Vision
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 堀江 幸弘

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