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Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.

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Title: Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.
Authors: Horie, Yukihiro Browse this author
Kitaichi, Nobuyoshi Browse this author →KAKEN DB
Takemoto, Yuko Browse this author →KAKEN DB
Namba, Kenichi Browse this author →KAKEN DB
Yoshida, Kazuhiko Browse this author →KAKEN DB
Hirose, Shigeto Browse this author
Hasumi, Yukiko Browse this author
Ota, Masao Browse this author
Inoko, Hidetoshi Browse this author
Mizuki, Nobuhisa Browse this author
Ohno, Shigeaki Browse this author →KAKEN DB
Issue Date: 21-Dec-2007
Publisher: Molecular Vision
Journal Title: Molecular Vision
Volume: 13
Start Page: 2334
End Page: 2338
PMID: 18199975
Abstract: PURPOSE: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanagi-Harada (VKH) disease. The aim of this study was to determine the IFN-gamma gene polymorphisms in VKH disease. METHODS: The study involved 136 VKH patients and 176 healthy controls, who were genotyped for functional single nucleotide polymorphism (SNP; rs2430561; A/T) and functional microsatellite (CA) repeats (rs3138557) in the first intron of the IFN-gamma gene. Moreover, clinical manifestations of the patients were also analyzed. RESULTS: Diffuse choroiditis/staining of fluorescein angiography was seen in all VKH patients in this study. Sunset glow fundus and nummular chorioretinal depigmented scars were observed in 83.9%, and 36.1% of the patients, respectively. Neurological and auditory disorders were observed in 90.1% of the patients: meningismus (79.8%), tinnitus (53.0%), and cerebrospinal fluid pleocytosis (70.0%). Dermatologic manifestations were observed in 22.9% of the patients, manifesting as alopecia (6.9%), poliosis (17.6%), and vitiligo (13.0%). In addition, 22.1% of the patients were classified as having complete VKH disease, while 65.4% as having incomplete VKH disease, and 12.5% as having probable VKH disease. There were no significant differences in the allele and genotype frequencies between VKH patients and healthy controls. In addition, we found no association between each clinical manifestation and SNP (re2430561) in the healthy control subject. A strong linkage disequilibrium (LD) was found in the functional SNP T allele and functional microsatellite 12 (CA) repeats (D'=0.96-0.99). CONCLUSIONS: The functional SNP T allele and microsatellite 12 (CA) repeats were found to have a strong LD, although a genetic susceptibility for the IFN-gamma gene could not be demonstrated among the Japanese VKH patients.
Rights: Copyright (c) 2007 Molecular Vision
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 堀江 幸弘

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