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A BOLD-fMRI study of cerebral activation induced by injection of algesic chemical substances into the anesthetized rat forepaw

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.56.2.99

Title: A BOLD-fMRI study of cerebral activation induced by injection of algesic chemical substances into the anesthetized rat forepaw
Authors: Asanuma, Taketoshi Browse this author
Yasui, Hironobu Browse this author
Sato, Masayasu Browse this author
Inanami, Osamu Browse this author →KAKEN DB
Kuwabara, Mikinori Browse this author
Keywords: anesthetization
formalin
functional MRI
pain
somatosensory cortex
Issue Date: Aug-2008
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 56
Issue: 2
Start Page: 99
End Page: 107
Abstract: This study was performed to examine whether the brain activities induced by noxious algesic chemical substances in anesthetized animals could be detected by blood oxygen-leveldependent functional magnetic resonance imaging (BOLD-fMRI). Multislice gradient echo images of the primary somatosensory cortex were obtained using a 7.05 T superconducting system and a one-turned surface coil centered over the primary somatosensory cortex of the 1.0%- isoflurane-anesthetized rat. The Z-score t-map of BOLD signals and its time-course analysis revealed that subcutaneous injection of formalin into the left forepaw immediately induced an early response in the contralateral primary sensory cortex lasting for a few minutes, followed by a late response until 20 min after stimulation. In contrast, injection of capsaicin into the left forepaw evoked only the early response. Furthermore, pretreatment with morphine completely abolished these responses induced by the chemical algesic substances. Thus BOLD-fMRI is a useful method to analyze the brain activities of painful stimulation in anesthetized animals.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/34677
Appears in Collections:Japanese Journal of Veterinary Research > Volume 56, Number 2

Submitter: 獣医学部図書室

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