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Volume 56, Number 2 >

Downregulation of male-specific cytochrome P450 by profenofos

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Title: Downregulation of male-specific cytochrome P450 by profenofos
Authors: Moustafa, Gihan G. Browse this author
Ibrahim, Zein S. Browse this author
Ahmed, Mohamed M. Browse this author
Ghoneim, Mervat H. Browse this author
Sakamoto, Kentaro Q. Browse this author →KAKEN DB
Ishizuka, Mayumi Browse this author →KAKEN DB
Fujita, Shoichi Browse this author
Keywords: aromatase
cytochrome P450
Issue Date: Aug-2008
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 56
Issue: 2
Start Page: 109
End Page: 118
Abstract: The health hazards of individual organophosphorus insecticides have been characterized by their acute toxicity, mainly by investigating their cholinesterase inhibition. However, the chronic effects of most of these toxicants on the drug-metabolizing enzymes have not been investigated. Profenofos (O-4-bromo-2-chlorophenyl O-ethyl S-propyl phosphorothioate) is an organophosphorus pesticide widely used in cotton cultivation. In the present study, we investigated the effect of profenofos on male-specific cytochrome P450 (CYP) enzymes in adult Wistar rats. We orally administered 17.8 mg/kg body weight, twice weekly for 65 days. Profenofos downregulated levels of hepatic and testicular CYP2C11 and CYP3A2 mRNA and protein expression. Testicular aromatase (CYP19A) mRNA was decreased in the profenofos-treated rats compared to controls. Overall, the present study suggests that profenofos acts as an endocrine disruptor of male-specific CYP enzymes and affects testosterone concentration, which implicates its deleterious effects on animal or human males chronically exposed to organophosphorus pesticide.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 56, Number 2

Submitter: 獣医学部図書室

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