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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Stimulus frequency dependence of blood oxygenation level-dependent functional magnetic resonance imaging signals in the somatosensory cortex of rats
| Title: | Stimulus frequency dependence of blood oxygenation level-dependent functional magnetic resonance imaging signals in the somatosensory cortex of rats |
| Authors: | Kida, Ikuhiro Browse this author | | Yamamoto, Toru Browse this author →KAKEN DB |
| Keywords: | blood oxygenation level-dependent | | cerebral blood flow | | forepaw stimulation | | functional magnetic resonance imaging | | metabolism | | optical imaging |
| Issue Date: | Sep-2008 |
| Publisher: | Elsevier |
| Journal Title: | Neuroscience Research |
| Volume: | 62 |
| Issue: | 1 |
| Start Page: | 25 |
| End Page: | 31 |
| Publisher DOI: | 10.1016/j.neures.2008.05.006 |
| PMID: | 18602178 |
| Abstract: | Understanding the mechanism Of Coupling between neuronal events and hemodynamic responses is important in non-invasive functional imaging of the brain. The stimulus frequency dependence of hemodynamic responses has been studied using a rat somatosensory cortex model most results for short stimulus durations reveal peak frequencies at which the hemodynamic response is maximized. However, such peak frequencies have not been observed in studies using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals with long stimulus durations. To clarify whether the stimulus frequency dependence of BOLD signals depends on the stimulus duration, we measured BOLD signals at 7 T with short- and long-stimulus durations for stimulating rat forepaw at 1-10 Hz using spin-echo echo-planar imaging to enhance changes in activation focus. For both these durations, BOLD signals were significantly higher at stimulus frequencies of 3 or 5 Hz in agreement with the results of previous studies using optical techniques. Our results show that stimulus duration has little influence on the stimulus frequency dependence of BOLD signals in the rat somatosensory model. The discrepant results of most previous fMRI studies using gradient-echo sequence may be ascribed to the difference of imaging to enhance activation focus or draining vein. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
| Relation: | http://www.sciencedirect.com/science/journal/01680102 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/34759 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 黄田 育宏
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