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Regulation of cell survival and death signals induced by oxidative stress

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Title: Regulation of cell survival and death signals induced by oxidative stress
Authors: Kuwabara, Mikinori Browse this author
Asanuma, Taketoshi Browse this author
Niwa, Koichi Browse this author →KAKEN DB
Inanami, Osamu Browse this author →KAKEN DB
Keywords: oxidative stress
Issue Date: Sep-2008
Publisher: 日本酸化ストレス学会
Journal Title: Journal of Clinical Biochemistry and Nutrition
Volume: 43
Issue: 2
Start Page: 51
End Page: 57
Publisher DOI: 10.3164/jcbn.2008045
PMID: 18818753
Abstract: Oxidative stress stimulates two opposite signaling pathways leading to cell death and cell survival. Preferential selection of survival signals leads to the protection of cells against damage induced by reactive oxygen species, whereas preferential acceleration of death signals can be used to advantage in tumor therapy with oxidizing agents such as ionizing radiation and anticancer drugs. In vitro and in vivo experiments using cultured mammalian cells and experimental animals showed that ERK was included in survival signals and SAPK and p38 MAPK in death signals in oxidative stress. The activation of SAPK/JNK and subsequent expression of death receptor Fas on the cell surface caused the induction of cell death. The results mean that the acceleration of the activation of SAPK/JNK might lead to the enhancement of cell death by oxidizing agents like ionizing radiation and anticancer drugs. In fact, when cultured mammalian cells were exposed to ionizing radiation with 2-nitroimidazole derivatives having electrophilicity, the lethal effect of ionizing radiation was found to be enhanced together with the activation of SAPK/JNK and the enhancement of Fas expression. The activation of both survival and death signals was suppressed by the antioxidants Nacetylcystein and Trolox, suggesting that both signaling pathways are redox-regulated.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 稲波 修

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