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Volume 56, Number 3 >

Polymorphism in MRL and AKR mice Sry : a candidate gene for the appearance of testicular oocyte

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Title: Polymorphism in MRL and AKR mice Sry : a candidate gene for the appearance of testicular oocyte
Authors: Otsuka, Saori Browse this author
Konno, Akihiro Browse this author
Hashimoto, Yoshiharu Browse this author
Sasaki, Nobuya Browse this author →KAKEN DB
Endoh, Daiji Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: AKR
glutamine repeat
testicular oocyte
Issue Date: Nov-2008
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 56
Issue: 3
Start Page: 129
End Page: 138
Abstract: Although mammals produce either sperm or eggs depending on their sex, newborn MRL/MpJ male mice contain oocytes within their testes. In our previous study, the testicular oocyte appears as early as day 0 afterbirth and has morphological characteristics as an oocyte such as zona pellucida and follicular epithelial cells. Based on the observation of F1 between MRL/MpJ and C57BL/6, one of the genes causing the appearance of testicular oocyte exists on the Y chromosome. In the present study, we found testicular oocytes within newborn AKR mice. We have also analyzed the Sry genes from several inbred mouse strains and identified a shortened glutamine repeat near the C-terminal region that is unique to MRL and AKR. These results suggest that polymorphism of glutamine repeat within SRY correlates with the appearance of testicular oocyte and this phenotype is derived from AKR, one of the original strains of MRL mice.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 56, Number 3

Submitter: 獣医学部図書室

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