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Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process

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Title: Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process
Authors: Sato, Mari M. Browse this author
Nashimoto, Masayuki Browse this author
Katagiri, Takenobu Browse this author
Yawaka, Yasutaka Browse this author
Tamura, Masato Browse this author →KAKEN DB
Keywords: miR-206
miRNA processing
bone morphogenetic protein
Smad
myoblasts
Issue Date: 22-May-2009
Publisher: Academic Press
Journal Title: Biochemical and Biophysical Research Communications
Volume: 383
Issue: 1
Start Page: 125
End Page: 129
Publisher DOI: 10.1016/j.bbrc.2009.03.142
PMID: 19341710
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that are emerging as important post-transcriptional gene regulators. miR-206 is unique in that it is expressed only in skeletal muscle, including the myoblastic C2C12 cell line. In C2C12 cells, miR-206 expression was reduced dramatically after bone morphogenetic protein (BMP)-2 treatment. The down-regulation of miR-206 expression was also observed after co-transfection with constitutively-active Smad1 and Smad4, which are the intracellular signaling molecules of the BMP pathway. BMP-2 also reduced miR-206 expression in the presence of α-amanitin in a similar manner to that in the absence of α-amanitin. Moreover, the expression of pri-miR-206 was increased upon BMP-2 treatment for 6 hours compared to that in the absence of BMP-2. These results suggested that BMP-2 down-regulates miR-206 expression at the post-transcriptional level, by inhibiting the processing of pri-miR-206 into mature miR-206, and that BMP-2 could regulate miRNA biogenesis by a novel mechanism.
Type: article (author version)
URI: http://hdl.handle.net/2115/38314
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田村 正人

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