Stereochemical studies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/38549

Title:	Stereochemical studies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction
Authors:	Nakahashi, Atsufumi Browse this author
	Miura, Nobuaki Browse this author
	Monde, Kenji Browse this author →KAKEN DB
	Tsukamoto, Sachiko Browse this author
Keywords:	VCD
	Enantiomers
	p53
	HDM2
	Enantioseparation
	α-Alkyl carboxylic acid
Issue Date:	1-Jun-2009
Publisher:	Elsevier Ltd.
Journal Title:	Bioorganic & Medicinal Chemistry Letters
Volume:	19
Issue:	11
Start Page:	3027
End Page:	3030
Publisher DOI:	10.1016/j.bmcl.2009.04.057
PMID:	19414261
Abstract:	Hexylitaconic acid (1) is an intriguing natural product possessing a chiral carbon, and both its enantiomers have been found in nature. Enantiomeric pure (+)-(1) and (-)-(1) were successfully prepared by racemic synthesis followed by enantiomeric separation in a chiral HPLC system. Their absolute configurations were clarified by the vibrational circular dichroism technique using their methyl esters 2 and lactones 3. Their inhibitory activities against the interaction of p53-HDM2 were also examined.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/38549
Appears in Collections:	生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 門出健次

OAI-PMH ( junii2 , jpcoar_1.0 )

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