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Stereochemical studies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction

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Title: Stereochemical studies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction
Authors: Nakahashi, Atsufumi Browse this author
Miura, Nobuaki Browse this author
Monde, Kenji Browse this author →KAKEN DB
Tsukamoto, Sachiko Browse this author
Keywords: VCD
Enantiomers
p53
HDM2
Enantioseparation
α-Alkyl carboxylic acid
Issue Date: 1-Jun-2009
Publisher: Elsevier Ltd.
Journal Title: Bioorganic & Medicinal Chemistry Letters
Volume: 19
Issue: 11
Start Page: 3027
End Page: 3030
Publisher DOI: 10.1016/j.bmcl.2009.04.057
PMID: 19414261
Abstract: Hexylitaconic acid (1) is an intriguing natural product possessing a chiral carbon, and both its enantiomers have been found in nature. Enantiomeric pure (+)-(1) and (-)-(1) were successfully prepared by racemic synthesis followed by enantiomeric separation in a chiral HPLC system. Their absolute configurations were clarified by the vibrational circular dichroism technique using their methyl esters 2 and lactones 3. Their inhibitory activities against the interaction of p53-HDM2 were also examined.
Type: article (author version)
URI: http://hdl.handle.net/2115/38549
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 門出 健次

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