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Pharmacokinetics and the most suitable regimen of panipenem/beta mipron in critically ill patients receiving continuous renal replacement therapy : a pilot study
| Title: | Pharmacokinetics and the most suitable regimen of panipenem/beta mipron in critically ill patients receiving continuous renal replacement therapy : a pilot study |
| Other Titles: | Pharmacokinetics and the most suitable regimen of panipenem/betamipron in critically ill patients receiving continuous renal replacement therapy : a pilot study |
| Authors: | Hayakawa, Mineji Browse this author | | Ito, Yasuko Browse this author | | Fujita, Itaru Browse this author | | Iseki, Ken Browse this author →KAKEN DB | | Gando, Satoshi Browse this author |
| Keywords: | pharmacokinetics | | carbapenems | | kidney failure | | hemofiltration | | metabolic clearance rate |
| Issue Date: | Jul-2006 |
| Publisher: | Lippincott Williams & Wilkins |
| Journal Title: | ASAIO Journal |
| Volume: | 52 |
| Issue: | 4 |
| Start Page: | 398 |
| End Page: | 403 |
| Publisher DOI: | 10.1097/0.1mat.0000225268.28044.ae |
| Abstract: | Critically ill patients are often complicated with acute renal failure induced by severe infection or sepsis. The patients need administration of broad-spectrum antibiotics as well continuous renal replacement therapy (CRRT). However, there is no uniform pharmacokinetics of antibiotics during the CRRT because CRRT is performed with the various combinations of dialysate flows (QD) and ultrafiltrate flows (QF). The aims of this study were to estimate the pharmacokinetics of panipenem/betamipron (PAPM/BP) and to determine the appropriate treatment regimens for PAPM/BP in critically ill patients undergoing CRRT. In patients with CRRT, the PAPM total clearance (PAPM CLtot) was calculated as the sum of PAPM clearance dependent on the living body and CRRT and shown as follow: PAPM CLtot (ml/min) = (1.2 CLcre+ 66.5) + 0.86 (QD+QF) where CLcre is creatinine clearance. Pharmacokinetic values of PAPM were measured in 4 patients with CRRT. According to these results, the most appropriate treatment regimen regarding PAPM CLtot (ml/min) showed as follows: {PAPM CLtot < 80} {0.5 g every 12 hr or 1 g every 15 hr} {PAPM CLtot 80-120} {0.5 g every 8 hr or 1 g every 12 hr} {PAPM CLtot 120-160} {0.5 g every 6 hr or 1 g every 8 hr} |
| Rights: | This is a non-final version of an article published in final form in ASAIO Journal. 52(4):398-403, July/August 2006 |
| Relation: | http://www.asaiojournal.com/pt/re/asaio/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/38597 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 早川 峰司
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