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Pharmacokinetics and the most suitable regimen of panipenem/beta mipron in critically ill patients receiving continuous renal replacement therapy : a pilot study

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Title: Pharmacokinetics and the most suitable regimen of panipenem/beta mipron in critically ill patients receiving continuous renal replacement therapy : a pilot study
Other Titles: Pharmacokinetics and the most suitable regimen of panipenem/betamipron in critically ill patients receiving continuous renal replacement therapy : a pilot study
Authors: Hayakawa, Mineji Browse this author
Ito, Yasuko Browse this author
Fujita, Itaru Browse this author
Iseki, Ken Browse this author
Gando, Satoshi Browse this author
Keywords: pharmacokinetics
carbapenems
kidney failure
hemofiltration
metabolic clearance rate
Issue Date: Jul-2006
Publisher: Lippincott Williams & Wilkins
Journal Title: ASAIO Journal
Volume: 52
Issue: 4
Start Page: 398
End Page: 403
Abstract: Critically ill patients are often complicated with acute renal failure induced by severe infection or sepsis. The patients need administration of broad-spectrum antibiotics as well continuous renal replacement therapy (CRRT). However, there is no uniform pharmacokinetics of antibiotics during the CRRT because CRRT is performed with the various combinations of dialysate flows (QD) and ultrafiltrate flows (QF). The aims of this study were to estimate the pharmacokinetics of panipenem/betamipron (PAPM/BP) and to determine the appropriate treatment regimens for PAPM/BP in critically ill patients undergoing CRRT. In patients with CRRT, the PAPM total clearance (PAPM CLtot) was calculated as the sum of PAPM clearance dependent on the living body and CRRT and shown as follow: PAPM CLtot (ml/min) = (1.2 CLcre+ 66.5) + 0.86 (QD+QF) where CLcre is creatinine clearance. Pharmacokinetic values of PAPM were measured in 4 patients with CRRT. According to these results, the most appropriate treatment regimen regarding PAPM CLtot (ml/min) showed as follows: {PAPM CLtot < 80} {0.5 g every 12 hr or 1 g every 15 hr} {PAPM CLtot 80-120} {0.5 g every 8 hr or 1 g every 12 hr} {PAPM CLtot 120-160} {0.5 g every 6 hr or 1 g every 8 hr}
Rights: This is a non-final version of an article published in final form in ASAIO Journal. 52(4):398-403, July/August 2006
Relation URI: http://www.asaiojournal.com/pt/re/asaio/
Type: article (author version)
URI: http://hdl.handle.net/2115/38597
Appears in Collections:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

 

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