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A Prospective Comparative Study of Three Sets of Criteria for Disseminated Intravascular Coagulation : ISTH Criteria vs Japanese Criteria

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Title: A Prospective Comparative Study of Three Sets of Criteria for Disseminated Intravascular Coagulation : ISTH Criteria vs Japanese Criteria
Authors: Hayakawa, Mineji Browse this author
Gando, Satoshi Browse this author
Hoshino, Hirokatsu Browse this author
Keywords: Disseminated intravascular coagulation
Diagnostic criteria
Hemostatic disorders
International Society on Thrombosis and Haemostasis
Japan
Issue Date: Jan-2007
Publisher: SAGE Publications
Journal Title: Clinical and Applied Thrombosis/Hemostasis
Volume: 13
Issue: 1
Start Page: 65
End Page: 72
Publisher DOI: 10.1177/1076029606296405
PMID: 17164497
Abstract: Clinical and laboratory criteria and a scoring system for disseminated intravascular coagulation (DIC) were recently published by the International Society on Thrombosis and Haemostasis (ISTH). In Japan, the DIC Diagnostic Standards published in 1988 have been widely used for more than 10 years. In a general intensive care unit, we prospectively compared the diagnostic properties of the overt DIC, non-overt DIC, and Japanese DIC criteria sets, and investigated the influences of each set on patient morbidity and mortality. Seventy-four patients with platelet counts below 150 x 10^9/L were included in this study. Blood samples were collected daily from day 0 to day 4 after inclusion in the study. The Japanese DIC included the overt DIC and both of these were included in the non-overt DIC. The Japanese DIC criteria diagnosed DIC earlier than the non-overt DIC criteria did (p = 0.020). The DIC patients diagnosed by the Japanese criteria and those diagnosed by the overt DIC criteria showed a higher incidence of multiple organ failure than those without DIC (p = 0.013 and p = 0.022, respectively). The Japanese and the non-overt DIC criteria tended to predict patient prognoses effectively. In conclusion, the Japanese and the non-overt DIC criteria are of value in predicting outcome. However, the non-overt DIC criteria take more time to diagnose DIC than the Japanese criteria do. A more precise clinical study is needed to determined appropriate specific criteria and cut-ff points in the non-overt DIC criteria set.
Type: article (author version)
URI: http://hdl.handle.net/2115/38599
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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