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Studies on a New Virus (OMV) from Oncorhynchus masou. II, Oncogenic Nature

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Title: Studies on a New Virus (OMV) from Oncorhynchus masou. II, Oncogenic Nature
Authors: Kimura, Takahisa Browse this author →KAKEN DB
Yoshimizu, Mamoru Browse this author →KAKEN DB
Tanaka, Makoto Browse this author
Issue Date: Mar-1981
Publisher: 日本魚病学会
Journal Title: 魚病研究
Journal Title(alt): Fish pathology
Volume: 15
Issue: 3/4
Start Page: 149
End Page: 153
Abstract: Among survivors of experimental infection of herpesvirus OMV which was considered to be a new viral pathogen of salmonids producing hepatic necrosis and significant mortality, more than 60% developed tumors. The perioral maxillary and mandibular region are the most frequent site of tumor formation. In decreasing order of frequency, tumors were also found on the caudal fin, gill-cover, eye, and kidney. Histopathologically the tumors were composed of abundantly proliferative, well differentiated epithelial cells supported by fine connective tissue stroma. Although virus particles were not observed in tumor cells, OMV isolation was successful from a tumor tissue sample that appeared necrotic on day 275 postinfection and from primary cultures of a tumor tissue from another fish sampled 296 days postinfection. From the evidence thus far obtained, OMV is considered to be a new pathogenic and oncogenic salmon virus. It is the first oncogenic agent to be isolated from fish.
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉水 守

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