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Incidence and Risk of Postherpetic Neuralgia after Varicella Zoster Virus Infection in Hematopoietic Cell Transplantation Recipients: Hokkaido Hematology Study Group

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Title: Incidence and Risk of Postherpetic Neuralgia after Varicella Zoster Virus Infection in Hematopoietic Cell Transplantation Recipients: Hokkaido Hematology Study Group
Authors: Onozawa, Masahiro Browse this author
Hashino, Satoshi Browse this author
Haseyama, Yoshifumi Browse this author
Hirayama, Yasuo Browse this author
Iizuka, Susumu Browse this author
Ishida, Tadao Browse this author
Kaneda, Makoto Browse this author
Kobayashi, Hajime Browse this author
Kobayashi, Ryoji Browse this author
Koda, Kyuhei Browse this author
Kurosawa, Mitsutoshi Browse this author
Mosauji, Nobuo Browse this author
Matsunaga, Takuya Browse this author
Mori, Akio Browse this author
Mukai, Masaya Browse this author
Nishio, Mitsufumi Browse this author
Noto, Satoshi Browse this author
Ota, Shuichi Browse this author
Sakai, Hajime Browse this author
Suzuki, Nobuhiro Browse this author
Takahashi, Tohru Browse this author
Tanaka, Junji Browse this author →KAKEN DB
Torimoto, Yoshihiro Browse this author
Yoshida, Makoto Browse this author
Fukuhara, Takashi Browse this author
Keywords: Varicella zoster virus
Postherpetic neuralgia
Disseminated zoster
Visceral zoster
Issue Date: Jun-2009
Publisher: Elsevier Inc.
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 15
Issue: 6
Start Page: 724
End Page: 729
Publisher DOI: 10.1016/j.bbmt.2009.03.003
PMID: 19450757
Abstract: To assess the incidence of and risk factors associated with post-herpetic neuralgia (PHN) after post-hematopoietic cell transplantation (HCT) varicella-zoster virus (VZV) infection, we conducted a retrospective chart review of 418 consecutive patients who underwent HCT between April 2005 and March 2007. Male/female ratio was 221/197, median age at HCT was 47 years (range: 0-69 years), and autologous/allogeneic/syngeneic HCT ratio was 154/263/1. Seventy-eight patients developed VZV infection after HCT. Sixty-two patients had localized zoster, 11 patients had disseminated zoster (rash like chicken pox), and 4 patients had visceral zoster. All cases were treated with acyclovir (ACV) or valacyclovir (VACV), and there was no VZV infection-related death. Twenty-seven (35%) of the 78 patients with VZV infection suffered PHN after resolution of VZV infection. Multivariate analysis showed that advanced age is the only risk factor in autologous HCT (P = 0.0075; OR = 1.14; 95% Cl, 0.97 to 1.33). On the other hand, advanced age (P = 0.0097; OR = 1.06; 95% Cl, 1.01 to 1.12), male gender (P = 0.0055; OR = 12.7; 95% Cl, 1.61 to 100.1), and GVHD prophylaxis with a tacrolimus-based regimen (P = 0.0092; OR = 9.56; 95% Cl, 1.44 to 63.3) were associated with increased risk of PHN in allogeneic HCT. This study for the first time clarified the risk of PHN in HCT recipients.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤 真弘

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