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Strain differences of cerebral ventricles in mice: Can the MRL/MpJ mouse be a model for hydrocephalus?

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Title: Strain differences of cerebral ventricles in mice: Can the MRL/MpJ mouse be a model for hydrocephalus?
Authors: Hino, Keisuke Browse this author
Otsuka, Saori Browse this author →KAKEN DB
Ichii, Osamu Browse this author →KAKEN DB
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: cerebral ventricle
ependymal cells
Issue Date: May-2009
Publisher: The Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 57
Issue: 1
Start Page: 3
End Page: 11
Abstract: Hydrocephalus is an intractable disease characterized by the excessive accumulation of cerebrospinal fluid (CSF) in the cerebral ventricles. There are many cases in both human and animals; however, the cause and mechanism of it's development is not clearly understood. In this study, differences of cerebral ventricles in 5 inbred mice strains (MRL/MpJ, C57BL/6, C3H/He, DBA/2 and BALB/c) were investigated by histological techniques to determine the possibility of a new animal model for hydrocephalus. Our analysis showed that significant differences in the volume and the surface area of lateral ventricles in the 5 inbred strains, with MRL/MpJ mice having the largest lateral, third, aqueduct and fourth ventricles. In addition, when MRL/MpJ mice were compared to BALB/c mice on 0 day after birth, the former already had larger lateral ventricles than the latter. Although there were no significant difference in the ratios of ependymal cell types in MRL/MpJ mice and BALB/c mice, the number and the diameter of lipid droplets in MRL/MpJ mice were, interestingly, smaller than those in BALB/c mice. It is well known that ependymal cells absorb nutritional substances in CSF by endocytosis, suggesting the possibility that their decrease may relate to the larger cerebral ventricles in MRL/MpJ. In conclusion, MRL/MpJ mice have greater volumes in cerebral ventricles than other strains and may be useful for a model showing high susceptibility to hydrocephalus.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 57, Number 1

Submitter: 獣医学部図書室

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