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Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients

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Title: Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
Authors: Horie, Yukihiro Browse this author
Kitaichi, Nobuyoshi Browse this author →KAKEN DB
Katsuyama, Yoshihiko Browse this author
Yoshida, Kazuhiko Browse this author →KAKEN DB
Miura, Toshie Browse this author
Ota, Masao Browse this author
Asukata, Yuri Browse this author
Inoko, Hidetoshi Browse this author
Mizuki, Nobuhisa Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Ohno, Shigeaki Browse this author →KAKEN DB
Issue Date: 3-Jun-2009
Publisher: Molecular Vision
Journal Title: Molecular Vision
Volume: 15
Start Page: 1115
End Page: 1119
PMID: 19503742
Abstract: Purpose: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder against melanocytes. Polymorphisms of the protein tyrosine phosphatase non-receptor 22 gene (PTPN22) have recently been reported to be associated with susceptibility to several autoimmune diseases. In this study, genetic susceptibility to VKH disease was investigated by screening for single nucleotide polymorphisms (SNPs) of PTPN22. Methods: A total of 167 Japanese patients with VKH disease and 188 healthy Japanese controls were genotyped by direct sequencing methods for six SNPs (rs3811021, rs1217413, rs1237682, rs3761935, rs3789608, and rs2243471) of PTPN22 including the uncoding exons. Results: The six SNPs in PTPN22 showed no significant association with susceptibility to VKH disease or its ocular, neurologic, or dermatological manifestation. Conclusions: Further studies are needed to clarify the genetic mechanisms underlying VKH disease.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 堀江 幸弘

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