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Hokkaido University Collection of Scholarly and Academic Papers >
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Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
| Title: | Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients |
| Authors: | Horie, Yukihiro Browse this author | | Kitaichi, Nobuyoshi Browse this author →KAKEN DB | | Katsuyama, Yoshihiko Browse this author | | Yoshida, Kazuhiko Browse this author →KAKEN DB | | Miura, Toshie Browse this author | | Ota, Masao Browse this author | | Asukata, Yuri Browse this author | | Inoko, Hidetoshi Browse this author | | Mizuki, Nobuhisa Browse this author | | Ishida, Susumu Browse this author →KAKEN DB | | Ohno, Shigeaki Browse this author →KAKEN DB |
| Issue Date: | 3-Jun-2009 |
| Publisher: | Molecular Vision |
| Journal Title: | Molecular Vision |
| Volume: | 15 |
| Start Page: | 1115 |
| End Page: | 1119 |
| PMID: | 19503742 |
| Abstract: | Purpose: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder against melanocytes. Polymorphisms of the protein tyrosine phosphatase non-receptor 22 gene (PTPN22) have recently been reported to be associated with susceptibility to several autoimmune diseases. In this study, genetic susceptibility to VKH disease was investigated by screening for single nucleotide polymorphisms (SNPs) of PTPN22. Methods: A total of 167 Japanese patients with VKH disease and 188 healthy Japanese controls were genotyped by direct sequencing methods for six SNPs (rs3811021, rs1217413, rs1237682, rs3761935, rs3789608, and rs2243471) of PTPN22 including the uncoding exons. Results: The six SNPs in PTPN22 showed no significant association with susceptibility to VKH disease or its ocular, neurologic, or dermatological manifestation. Conclusions: Further studies are needed to clarify the genetic mechanisms underlying VKH disease. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/38776 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 堀江 幸弘
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