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Development of a 3D collagen scaffold coated with multiwalled carbon nanotubes

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Title: Development of a 3D collagen scaffold coated with multiwalled carbon nanotubes
Authors: Hirata, Eri Browse this author
Uo, Motohiro Browse this author →KAKEN DB
Takita, Hiroko Browse this author →KAKEN DB
Akasaka, Tsukasa Browse this author
Watari, Fumio Browse this author
Yokoyama, Atsuro Browse this author
Keywords: carbon nanotubes
collagen sponge honeycomb
3D scaffolds
cell culture
Issue Date: Aug-2009
Publisher: Wiley
Journal Title: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Volume: 90b
Issue: 2
Start Page: 629
End Page: 634
Publisher DOI: 10.1002/jbm.b.31327
PMID: 19213050
Abstract: Carbon nanotubes (CNTs) have attractive biochemical properties such as strong cell adhesion and protein absorption, which are very useful for a cell cultivation scaffold. In this study, we prepared a multiwalled carbon nanotube-coated collagen sponge (MWCNT-coated sponge) to improve the surface properties of the collagen sponge, and its cell culturing properties were examined. The suface of the collagen sponge was homogeneously coated with MWCNTs by dispersion. MC3T3-E1 cells were cultured on and inside the MWCNT-coated sponge. The DNA content on the MWCNT-coated sponge after 1 week of culture was significantly higher than on an uncoated collagen sponge (p<0.05). There was no significant difference between the estimated ALP activity normalized by DNA quantity on the MWCNT-coated sponge and that on the uncoated collagen sponge which is well known as one of the best scaffolds for cell cultivation. In addition, the MWCNT-coated surface shows strong cell adhesion. Therefore, the MWCNT-coated collagen sponge is expected to be a useful 3D scaffold for cell cultivation.
Rights: This is the pre-peer reviewed version of the following article: Journal of Biomedical Materials Research, Part B, 90B(2), 2009, pp.629-634, which has been published in final form at
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宇尾 基弘

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