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Step-up therapy with biphasic insulin aspart-70/30 : Sapporo 1-2-3 study

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Title: Step-up therapy with biphasic insulin aspart-70/30 : Sapporo 1-2-3 study
Authors: Yoshioka, N. Browse this author →KAKEN DB
Kurihara, Y. Browse this author
Manda, N. Browse this author
Komori, K. Browse this author
Kato, M. Browse this author
Kijima, H. Browse this author
Wada, N. Browse this author
Yanagisawa, K. Browse this author
Aoki, S. Browse this author
Ono, Y. Browse this author
Koike, T. Browse this author →KAKEN DB
Keywords: Biphasic insulin aspart-30
Type 2 diabetes
Step-up insulin therapy
Clinical practice
Issue Date: Jul-2009
Publisher: Elsevier Ireland Ltd.
Journal Title: Diabetes Research and Clinical Practice
Volume: 85
Issue: 1
Start Page: 47
End Page: 52
Publisher DOI: 10.1016/j.diabres.2009.04.012
PMID: 19427051
Abstract: The effectiveness of BIAsp 30 step-up therapy in achieving glycemic control in Japanese patients with type 2 diabetes mellitus was investigated. Study subjects were 99 patients with type 2 diabetes mellitus aged over 20 years who were judged to require insulin therapy due to poor glucose control (HbA1c level of ≥ 7.5%). BIAsp 30 dosage was determined by the patient's attending physician; coadministration of hypotensive agents and antilipemic agents was permitted, but OAD coadministration was limited to patients already receiving such drugs at the start of the study. Patients who did not achieve HbA1c < 6.5% after 16±5 weeks with QD (Phase 1) were stepped up to BID (Phase 2). If patients still had not achieved HbA1c < 6.5% after 16±5 weeks with BID, they were stepped up to TID (Phase 3). 55 of the 99 enrolled subjects completed the study and the rates of achievement of HbA1c < 6.5% and HbA1c < 7.0% were 45.5% and 74.5% respectively. Of all registered subjects, 5.1% (5/99) achieved HbA1c < 6.5% in QD, 19.5% (16/82) in BID, and 20.6% (7/34) in TID. Statistically significant reductions in HbA1c levels were recorded at the conclusion of each phase, with no incidents requiring intervention, indicating that BIAsp 30 step-up therapy is a safe, simple therapy that can be useful in achieving better glycemic control for Japanese patients with type 2 diabetes mellitus.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉岡 成人

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