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Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats

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Title: Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats
Authors: Matsuzaki, Hirokazu Browse this author
Izumi, Takeshi Browse this author →KAKEN DB
Matsumoto, Machiko Browse this author
Togashi, Hiroko Browse this author
Yamaguchi, Taku Browse this author
Yoshida, Takayuki Browse this author
Watanabe, Masahiko Browse this author →KAKEN DB
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Keywords: 5-HT1A receptor
Early postnatal stress
Medial prefrontal cortex
Issue Date: 1-Aug-2009
Publisher: Elsevier B.V.
Journal Title: European Journal of Pharmacology
Volume: 615
Issue: 1-3
Start Page: 76
End Page: 82
Publisher DOI: 10.1016/j.ejphar.2009.05.012
PMID: 19470384
Abstract: Traumatic events in early life are associated with an increased risk of psychiatric diseases in adulthood. 5-hydroxytryptamine (5-HT)1A receptors are known to play a pivotal role in the 5-HTergic mechanisms associated with the etiology of stress-related disorders. The goal of the present study was to investigate whether early postnatal stress influences 5-HT1A receptor function in the medial prefrontal cortex in adult rats. Rats were subjected to aversive foot shock (FS) during the third week of the postnatal period (3wFS group). During the postadolescent period (10-14 weeks postnatal), immunohistochemical experiments were carried out to investigate c-Fos expression following the administration of R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a 5-HT1A receptor agonist. In the 3wFS group, the 8-OH-DPAT-induced c-Fos expression in the medial prefrontal cortex was significantly attenuated compared to that in the non-FS control group. A dual immunofluorescence study revealed that a small proportion of c-Fos positive cells co-express parvalbumin, and a relatively large proportion of c-Fos positive cells co-express glutaminase, suggesting that most c-Fos positive cells are glutamatergic neurons. We found that local perfusion of 8-OH-DPAT via a dialysis probe decreased extracellular 5-HT levels in the medial prefrontal cortex of the non-FS group, but not in the 3wFS group. However, the levels of 8-OH-DPAT-induced 5-HT syndrome were not significantly different between the non-FS and 3wFS groups. Therefore, aversive stress in the third week of the postnatal period attenuates 5-HT1A receptor function in the medial prefrontal cortex in adulthood and produces feedback inhibition of the raphe nuclei via postsynaptic 5-HT1A receptors.
Type: article (author version)
URI: http://hdl.handle.net/2115/38931
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 泉 剛

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