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Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma

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Title: Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma
Authors: Yoshioka, T. Browse this author
Miyamoto, M. Browse this author
Cho, Y. Browse this author
Ishikawa, K. Browse this author
Tsuchikawa, T. Browse this author
Kadoya, M. Browse this author
Li, L. Browse this author
Mishra, R. Browse this author
Ichinokawa, K. Browse this author
Shoji, Y. Browse this author
Matsumura, Y. Browse this author
Shichinohe, T. Browse this author →KAKEN DB
Hirano, S. Browse this author
Shinohara, T. Browse this author
Itoh, T. Browse this author
Kondo, S. Browse this author →KAKEN DB
Keywords: OSCC
Foxp3
Treg
anti-tumour immunity
prognosis
Issue Date: Apr-2008
Publisher: Nature Publishing Group
Journal Title: British Journal of Cancer
Volume: 98
Issue: 7
Start Page: 1258
End Page: 1263
Publisher DOI: 10.1038/sj.bjc.6604294
Abstract: CD4/8 status has been previously reported to be a critical factor in the prognosis of oesophageal squamous cell carcinoma (OSCC). In the current study, we investigated the effect of regulatory T cells (Treg; Foxp3; lymphocytes) on the status of CD4+ and CD8+ T cells in 122 patients with OSCC. Immunohistochemical analysis of Treg was performed using an antibody against Foxp3. The survival rate for low Foxp3 patients was significantly lower than for high Foxp3 patients (P=0.0028 by log-rank test), but Foxp3 status did not significantly correlate with prognosis in CD4/8(+/+) patients or CD4/8(+/-) or (-/+) patients (P=0.5185 and 0.8479, respectively, by log-rank test). We also found that Foxp3 status correlated with CD4/8 status (P=0.0002 by χ2 test) and that the variance of CD8/CD4 ratio in patients with low Foxp3 was larger than in patients with high Foxp3 (P<0.0001 by F-test). Thus, the results do not support the idea that Treg suppress anti-tumour immunity in patients with OSCC. Rather, the CD8/CD4 ratio and CD4/8 status appear to be critical factors in anti-tumour immunity. Furthermore, Treg numbers correlate with both the CD8/CD4 ratio and the CD4/8 status, suggesting that Treg number is not a factor to predict patient's survival in OSCC.
Rights: http://creativecommons.org/licenses/by-nc-nd/3.0/
Type: article
URI: http://hdl.handle.net/2115/39260
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Roshan Mishra

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