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Volume 57, Number 2 >

Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity

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Title: Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity
Authors: El Bohi, Khlood M. Browse this author
Hashimoto, Yoshiharu Browse this author
Muzandu, Kaampwe Browse this author
Ikenaka, Yoshinori Browse this author
Ibrahim, Zein Shaban Browse this author
Kazusaka, Akio Browse this author
Fujita, Shoichi Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: CCl4
cytochrome P450
Pleurotus cornucopiae
Issue Date: Aug-2009
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 57
Issue: 2
Start Page: 109
End Page: 118
Abstract: Pleurotus cornucopiae (PC) mushrooms are found in the field and commonly known in Japan as Tamogidake mushrooms. The present study investigated the protective effects of an aqueous extract of PC on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanism involved in this protection including cytochrome P450 (CYP) 2E1. Wistar rats were pretreated with aqueous extracts of PC (0, 100, 200, and 400 mg/kg) orally for 8 days prior to the intraperitoneal administration of a single dose of CCl4 (0.5 ml/kg) or corn oil. Pretreatment with PC mushroom extract significantly prevented the increased serum enzyme activities of alanine and aspartate aminotransferases in a dose-dependent manner, and suppressed the expression of CYP2E1. PC mushroom extract also protected hepatocytes from the damage effects of CCl4 as remarked by histological and electromicroscopical findings. It was concluded that repeated daily doses of aqueous extracts of PC mushroom reduced the toxic effects exerted by CCl4 on the liver.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 57, Number 2

Submitter: 獣医学部図書室

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