| Title: | Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation |
| Authors: | Tanaka, Junji Browse this author →KAKEN DB |
| Sugita, Junichi Browse this author |
| Asanuma, Shinsuke Browse this author |
| Arita, Kotaro Browse this author |
| Shono, Yusuke Browse this author |
| Kikutchi, Misato Browse this author |
| Shiratori, Souichi Browse this author |
| Wakasa, Kentaro Browse this author |
| Yasumoto, Atsushi Browse this author |
| Shigematu, Akio Browse this author |
| Kondo, Takeshi Browse this author →KAKEN DB |
| Kobayashi, Takahiko Browse this author |
| Asaka, Masahiro Browse this author |
| Imamura, Masahiro Browse this author |
| Keywords: | NK cell |
| Cord blood transplantation |
| Graft-versus-leukemia effect |
| Issue Date: | Sep-2009 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Human Immunology |
| Volume: | 70 |
| Issue: | 9 |
| Start Page: | 701 |
| End Page: | 705 |
| Publisher DOI: | 10.1016/j.humimm.2009.06.002 |
| PMID: | 19524005 |
| Abstract: | In the present study, we investigated subpopulations of NK cells and the expression of stimulatory and inhibitory NK receptors after adult blood and bone marrow transplantation (BBMT) and cord blood transplantation (CBT). There were significant increases in CD16(+)CD56(dim) cell proportion and in absolute number in peripheral blood mononuclear cells (PBMC) during a period of 4 months to 9 months after CBT compared with these in normal PBMC, cord blood (CB), and in PBMC after BBMT. Also, increased numbers of CD16(+)CD56(dim) NK cell sustained in some patients until 4 years after CBT. This CD16(+)CD56(dim) cell subset after CBT exhibited decreased expression of NKG2A compared with that in CB and increased expression of NKG2C. Purified CD16(+)CD56(dim) cells from patients 8-9 months after CBT exhibited significantly higher levels of cytolytic activity against K562 than did purified CD16(+)CD56(bright) cells and also whole PBMC. The CD16(+)CD56(dim) cell subset with a high level of cytolytic activity significantly increased after CBT, and these cells may be responsible for NK cell-mediated immunity after CBT. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/39350 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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