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Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation

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Title: Increased number of CD16(+)CD56(dim) NK cells in peripheral blood mononuclear cells after allogeneic cord blood transplantation
Authors: Tanaka, Junji Browse this author →KAKEN DB
Sugita, Junichi Browse this author
Asanuma, Shinsuke Browse this author
Arita, Kotaro Browse this author
Shono, Yusuke Browse this author
Kikutchi, Misato Browse this author
Shiratori, Souichi Browse this author
Wakasa, Kentaro Browse this author
Yasumoto, Atsushi Browse this author
Shigematu, Akio Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Kobayashi, Takahiko Browse this author
Asaka, Masahiro Browse this author
Imamura, Masahiro Browse this author
Keywords: NK cell
Cord blood transplantation
Graft-versus-leukemia effect
Issue Date: Sep-2009
Publisher: Elsevier Inc.
Journal Title: Human Immunology
Volume: 70
Issue: 9
Start Page: 701
End Page: 705
Publisher DOI: 10.1016/j.humimm.2009.06.002
PMID: 19524005
Abstract: In the present study, we investigated subpopulations of NK cells and the expression of stimulatory and inhibitory NK receptors after adult blood and bone marrow transplantation (BBMT) and cord blood transplantation (CBT). There were significant increases in CD16(+)CD56(dim) cell proportion and in absolute number in peripheral blood mononuclear cells (PBMC) during a period of 4 months to 9 months after CBT compared with these in normal PBMC, cord blood (CB), and in PBMC after BBMT. Also, increased numbers of CD16(+)CD56(dim) NK cell sustained in some patients until 4 years after CBT. This CD16(+)CD56(dim) cell subset after CBT exhibited decreased expression of NKG2A compared with that in CB and increased expression of NKG2C. Purified CD16(+)CD56(dim) cells from patients 8-9 months after CBT exhibited significantly higher levels of cytolytic activity against K562 than did purified CD16(+)CD56(bright) cells and also whole PBMC. The CD16(+)CD56(dim) cell subset with a high level of cytolytic activity significantly increased after CBT, and these cells may be responsible for NK cell-mediated immunity after CBT.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 淳司

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